Drug Product Development for the Back of the Eye

1. Selection of Drug Delivery Approaches for the Back of the Eye: Opportunities and Unmet Needs
David A. Marsh

2. Microdialysis for Vitreal Pharmacokinetics
Ravi D. Vaishya, Hari Krishna Ananthula, Ashim K. Mitra

3. Fluorophotometry for Pharmacokinetic Assessment
Bernard E. McCarey

4. Systemic Route for Retinal Drug Delivery: Role of the Blood-Retinal Barrier
Masanori Tachikawa, Vadivel Ganapathy, Ken-ichi Hosoya

5. Topical Drug Delivery to the Back of the Eye
Thomas Gadek, Dennis Lee

6. Principles of Retinal Drug Delivery from Within the Vitreous
Clive G. Wilson, Lay Ean Tan, Jenifer Mains

7. Transscleral Drug Delivery
Dayle H. Geroski, Henry F. Edelhauser

8. Suprachoroidal and Intrascleral Drug Delivery
Timothy W. Olsen, Brian C. Gilger

9. Advances in Biodegradable Ocular Drug Delivery Systems
Susan S. Lee, Patrick Hughes, Aron D. Ross, Michael R. Robinson

10. Microparticles as Drug Delivery Systems for the Back of the Eye
Rocío Herrero-Vanrell

11. Nanotechnology and Nanoparticles
Shelley A. Durazo, Uday B. Kompella

12. Hydrogels for Ocular Posterior Segment Drug Delivery
Gauri P. Misra, Thomas W. Gardner, Tao L. Lowe

13. Refillable Devices for Therapy of Ophthalmic Diseases
Alan L. Weiner

14. Targeted Drug Delivery to the Eye Enabled by Microneedles
Samirkumar R. Patel, Henry F. Edelhauser, Mark R. Prausnitz

15. Ocular Iontophoresis
Francine F. Behar-Cohen, Peter Milne, Jean-Marie Parel, Indu Persaud

16. Drug and Gene Therapy Mediated by Physical Methods
John M. Nickerson, Jeffrey H. Boatright

17. Protein Drug Delivery and Formulation Development
Rinku Baid, Puneet Tyagi, Shelley A. Durazo, Uday B. Kompella

18. Drug Suspension Development for the Back of the Eye
Jithan Aukunuru, Puneet Tyagi, Chandrasekar Durairaj, Uday B. Kompella

19. Regulatory Considerations in Product Development for Back of the Eye
Ashutosh A. Kulkarni

20. Clinical Endpoints for Back of the Eye Diseases
Karl G. Csaky

21. Druggable Targets and Therapeutic Agents for Disorders of the Back of the Eye
Robert I. Scheinman, Sunil K. Vooturi, Uday B. Kompella

22. Development of Bile Acids as Anti-Apoptotic and Neuroprotective Agents in Treatment of Ocular Disease
Stephanie L. Foster, Cristina Kendall, Allia K. Lindsay, Alison C. Ziesel, Rachael S. Allen, Sheree S. Mosley, Esther S. Kim, Ross J. Molinaro, Henry F. Edelhauser, Machelle T. Pardue, John M. Nickerson, Jeffrey H. Boatright

Avainsanat: Biomedicine, Pharmacology/Toxicology, Ophthalmology, Pharmaceutical Sciences/Technology