Metal Complex - DNA Interactions provides a comprehensive overview of this increasingly diverse field, presenting recent developments and the latest research with particular emphasis on metal-based drugs and metal ion toxicity. The text is divided into four parts:
- Basic Structural and Kinetic Aspects: includes chapters on sequence-selective metal binding to DNA and thermodynamic models.
- Medical Applications: focuses on anticancer platinum drugs, including discussions on DNA repair in antitumor effects of platinum drugs and photo-dynamic therapy.
- DNA-Recognition - Nucleases and Sensor: describes probes for DNA recognition, artificial restriction agents, metallo-DNAzymes for metal sensing applications and metal ion dependent catalysis in nucleic acid enzymes.
- Toxicological Aspects: deals with structural studies of mercury–DNA interactions, chromium-induced DNA damage and repair, and the effect of arsenic and nickel on DNA integrity.
This book will be a valuable resource for academic researchers and professionals from a range of pharmaceutical and chemical industries, particularly those involved in the development of new and less toxic anticancer metallo-drugs, and in the field of environmental and toxicological chemistry.
Avainsanat: Inorganic Chemistry