Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations

Updated with new chapters and topics, this book provides a comprehensive description of all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also features interactive computer simulations for students to experiment and observe PK/PD models in action.

• Presents the essentials of pharmacokinetics and pharmacodynamics in a clear and progressive manner
• Helps students better appreciate important concepts and gain a greater understanding of the mechanism of action of drugs by reinforcing practical applications in both the book and the computer modules
• Features interactive computer simulations, available online through a companion website at: https://web.uri.edu/pharmacy/research/rosenbaum/sims/
• Adds new chapters on physiologically based pharmacokinetic models, predicting drug-drug interactions, and pharmacogenetics while also strengthening original chapters to better prepare students for more advanced applications
• Reviews of the 1st edition: “This is an ideal textbook for those starting out … and also for use as a reference book …." (International Society for the Study of Xenobiotics) and “I could recommend Rosenbaum’s book for pharmacology students because it is written from a perspective of drug action . . . Overall, this is a well-written introduction to PK/PD …. “ (British Toxicology Society Newsletter)

Avainsanat:

PKPD; pharmacokinetics; pharmacodynamics; PK/PD models; PK/PD computer simulations; Sara Rosenbaum; drug action mechanisms; ADME; pharmacogenetics; physiologically based pharmacokinetic modeling; predictive models for drug-drug interactions; transporters; drug-drug interactions; drug administration; biopharmaceutics; bioavailability; drug dissolution; drug disintegration; non-compartmental analysis

, Clinical Pharmacology & Therapeutics, Pharmaceutical Statistics, Clinical Pharmacology & Therapeutics, Pharmaceutical Statistics