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El-Kattan, Ayman F.

Oral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development

El-Kattan, Ayman F. - Oral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development, e-kirja

164,55€

E-kirja, ePUB, Adobe DRM-suojattu
ISBN: 9781118916933
DRM-rajoitukset

Tulostus134 sivua ja lisä sivu kertyy joka 6. tunti, ylärajana 134 sivua
Kopioi leikepöydälle5 poimintoa

Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development.

• Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability
• Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development
• Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development
• Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)
• Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development

Avainsanat: Oral bioavailability; drug permeability; drug solubility; pharmacokinetics; physicochemical and biopharmaceutical parameters; drug metabolism; efflux transporters; uptake transporters; drug discovery and development; Extended Clearance Classification System (ECCS); first pass effect; fa; fg; fh; Biopharmaceutics Drug Disposition Classification System (BDDCS); preclinical and clinical development; in vitro and in vivo ADME assays, Analytical Chemistry, Clinical Pharmacology & Therapeutics, Analytical Chemistry, Clinical Pharmacology & Therapeutics

Tekijä(t)
 
Julkaisija
John Wiley and Sons, Inc.
Julkaisuvuosi
2017
Kieli
en
Painos
1
Sarja
Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods
Sivumäärä
448 sivua
Kategoria
Terveys, kauneus, muoti
Tiedostomuoto
E-kirja
eISBN (ePUB)
9781118916933
Painetun ISBN
9781118916698

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