El-Kattan, Ayman F.
Oral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development
• Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability
• Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development
• Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development
• Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)
• Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development
Avainsanat: Oral bioavailability; drug permeability; drug solubility; pharmacokinetics; physicochemical and biopharmaceutical parameters; drug metabolism; efflux transporters; uptake transporters; drug discovery and development; Extended Clearance Classification System (ECCS); first pass effect; fa; fg; fh; Biopharmaceutics Drug Disposition Classification System (BDDCS); preclinical and clinical development; in vitro and in vivo ADME assays, Analytical Chemistry, Clinical Pharmacology & Therapeutics, Analytical Chemistry, Clinical Pharmacology & Therapeutics
- Tekijä(t)
- El-Kattan, Ayman F.
- Lee, Mike S.
- Julkaisija
- John Wiley and Sons, Inc.
- Julkaisuvuosi
- 2017
- Kieli
- en
- Painos
- 1
- Sarja
- Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods
- Sivumäärä
- 448 sivua
- Kategoria
- Terveys, kauneus, muoti
- Tiedostomuoto
- E-kirja
- eISBN (ePUB)
- 9781118916933
- Painetun ISBN
- 9781118916698