Genotoxic Impurities: Strategies for Identification and Control

This book examines genotoxic impurities and their impact on the pharmaceutical industry.Specific sections examine this from both a toxicological and analytical perspective. Within these sections, the book defines appropriate strategies to both assess and ultimately control genotoxic impurities, thus aiding the reader to develop effective control measures. An opening section covers the development of guidelines and the threshold of toxicological concern (TTC) and is followed byasection on safety aspects, including safety tests in vivo and vitro, and data interpretation.The second section addresses the risk posed by genotoxic impurities fromoutside sources and from mutagenswithin DNA.In the final section, the book deals with the quality perspective of genotoxic impurities focused on two critical aspects, the first being the analysis and the second how to practically evaluate the impurities.

Avainsanat: Genotoxic Impurities, Analysis of genotoxic Impurities, Genetic Toxicity, Threshold of Toxicological Concern, Genotoxic Metabolites, EMEA guideline – Control of Genotoxic Impurities, FDA guideline, Genotoxic and Carcinogenic Impurities in Drug Substances and Products: Recommended Approaches, Genotoxic Degradants, Analytical Chemistry, Toxicology, Analytical Chemistry, Toxicology