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Foundation, Novartis

Purinergic Signalling in Neuron-Glia Interactions

Foundation, Novartis - Purinergic Signalling in Neuron-Glia Interactions, e-kirja

145,20€

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ISBN: 9780470032237
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Tulostus91 sivua ja lisä sivu kertyy joka 8. tunti, ylärajana 91 sivua
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ATP, the intracellular energy source, is also an extremely important cell–cell signalling molecule for a wide variety of cells across evolutionarily diverse organisms. The extracellular biochemistry of ATP and its derivatives is complex, and the multiple membrane receptors that it activates are linked to many intracellular signalling systems.

Purinergic signalling affects a diverse range of cellular phenomena, including ion channel function, cytoskeletal dynamics, gene expression, secretion, cell proliferation, differentiation and cell death.  Recently, this class of signalling molecules and receptors has been found to mediate communication between neurons and non-neuronal cells (glia) in the central and peripheral nervous systems. Glia are critical for normal brain function, development and response to injury. Neural impulse activity is detected by glia and purinergic signalling is emerging as a major means of integrating functional activity between neurons, glia and vascular cells in the nervous system. These interactions mediate effects of neural activity on the development of the nervous system and in association with injury, neurodegeneration, myelination and cancer.

Bringing together contributions from experts in diverse fields, including glial biologists, neurobiologists and specialists in purinergic receptor structure and pharmacology, this book considers how extracellular ATP acts to integrate communication between different types of glia, and between neurons and glia.  Beginning with an overview of glia and purinergic signalling, it contains detailed coverage of purine release, receptors and reagents, purinergic signalling in the neural control of glial development, glial involvement in information processing, and discussion of the interactions between neurons and microglia.

Avainsanat: SCIENCE / Life Sciences / Biochemistry SCI007000

Tekijä(t)
Julkaisija
John Wiley and Sons, Inc.
Julkaisuvuosi
2006
Kieli
en
Painos
1
Sarja
Novartis Foundation Symposia
Sivumäärä
302 sivua
Kategoria
Eksaktit luonnontieteet
Tiedostomuoto
E-kirja
eISBN (PDF)
9780470032237
Painetun ISBN
9780470018606

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