Current Hypotheses and Research Milestones in Alzheimer's Disease

1. Amyloid-ß: General Aspects

2. Role of A? Degrading Enzymes in Synaptic Plasticity and Neurogenesis in Alzheimer’s Disease
Leslie Crews, Brian Spencer, Eliezer Masliah

3. Pore-Forming Neurotoxin-Like Mechanism for A? Oligomer-Induced Synaptic Failure
Luis G. Aguayo, Jorge Parodi, Fernando J. Sepúlveda, Carlos Opazo

4. Interventions in Aging and Neurodegenerative Disease: Effects on Adult StemCells
Adam D. Bachstetter, Carmellina Gemma, Paula C. Bickford

2. Neuronal Cytoskeleton and the Tau Hypothesis

5. Tau Transgenic Mouse Models in Therapeutic Development
Hanno M. Roder

6. What Have We Learned from the Tau Hypothesis?
Ricardo B. Maccioni, Gustavo A. Farias, Leonel E. Rojo, M. Alejandra Sekler, Rodrigo O. Kuljis

7. Neuronal Cytoskeleton Regulation and Neurodegeneration
Ya-Li Zheng, Niranjana D. Amin, Parvathi Rudrabhatla, Sashi Kesavapany, Harish C. Pant

8. Stages of Pathological Tau-Protein Processing in Alzheimer’s Disease: From Soluble Aggregations to Polymerization into Insoluble Tau-PHFs

Raúl Mena, José Luna-Muñoz

9. Plasma Membrane-Associated PHF-Core Could be the Trigger for Tau Aggregation in Alzheimer’s Disease
Karla I. Lira-De León, Martha A. De Anda-Hernández, Victoria Campos-Peña, Marco A. Meraz-Ríos

3. Oxidative Stress Hypothesis

10. Neurofibrillary Tangle Formation as a Protective Response to Oxidative Stress in Alzheimer’s Disease
Akihiko Nunomura, Atsushi Takeda, Paula I. Moreira, Rudy J. Castellani, Hyoung-gon Lee, Xiongwei Zhu, Mark A. Smith, George Perry

4. Neuroimmunological Hypothesis

11. Inflammatory Processes Exacerbate Degenerative Neurological Disorders
Patrick L. McGeer, Edith G. McGeer, Claudia Schwab

12.
Central Nervous System Inflammation and Cholesterol Metabolism Alterations in the Pathogenesis of Alzheimer’s Disease and Their Diagnostic and Therapeutic Implications

Leonel E. Rojo, Jorge Fernández, José Jiménez, Andrea A. Maccioni, Alejandra Sekler, Rodrigo O. Kuljis, Ricardo B. Maccioni

13. Participation of Glial Cells in the Pathogenesis of AD: A Different View on Neuroinflammation
Rommy von Bernhardi

5. Cerebrovascular Pathology and AD

14. Cerebral and Cardiac Vascular Pathology in Alzheimer’s Disease
Jack C. de la Torre

15. Are Amyloids Infectious?
Rodrigo Morales, Baian Chen, Claudio Soto

16. The Possible Link Between Herpes Simplex Virus Type 1 Infection and Neurodegeneration
Carola Otth*, Angara Zambrano, Margarita Concha

6. General Aspects of AD Pathogenesis

17. Selective Cerebrocortical Regional, Laminar, Modular and Cellular Vulnerability and Sparing in Alzheimer’s Disease: Unexploited Clues to Pathogenesis, Pathophysiology, Molecular- and Systems-Level Hypothesis Generation and Experimental Testing
Kuljis Rodrigo O.

18. How Biochemical Pathways for Disease May be Triggered by Early-Life Events
Debomoy K. Lahiri, Bryan Maloney, Nasser H. Zawia

7. Biomarkers and AD

19. Strategies for Alzheimer's Disease Diagnosis
Lisbell D. Estrada, Claudio Soto

8. Cognitive Neurology in AD

20. The Diagnosis of Dementia in Subjects with Heterogeneous Educational Levels
Maria Teresa Carthery-Goulart, Paulo Caramelli, Ricardo Nitrini

21. Current Anti-Dementia Drugs: Hypothesis and Clinical Benefits
Patricio Fuentes

Avainsanat: Biomedicine, Psychiatry, Neurology, Neurosciences