Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications

Part I. Introduction

1. Overview of the Carbonic Anhydrase Family
Robert McKenna, Susan C. Frost

Part II. Carbonic Anhydrases: Ancient but Relevant

2. Physiological Functions of the Alpha Class of Carbonic Anhydrases
Susan C. Frost

3. Catalytic Mechanism of α-Class Carbonic Anhydrases: CO2 Hydration and Proton Transfer
Christopher D. Boone, Melissa Pinard, Rob McKenna, David Silverman

4. Structure and Catalytic Mechanism of β-Carbonic Anhydrases
Roger S. Rowlett

5. Prokaryotic Carbonic Anhydrases of Earth’s Environment
R. Siva Sai Kumar, James G. Ferry

6. Carboxysomal Carbonic Anhydrases
Matthew S. Kimber

7. Carbonic Anhydrases and Their Interplay with Acid/Base-Coupled Membrane Transporters
Holger M. Becker, Michael Klier, Joachim W. Deitmer

8. Carbonic Anhydrase Related Proteins: Molecular Biology and Evolution
Ashok Aspatwar, Martti E. E. Tolvanen, Csaba Ortutay, Seppo Parkkila

9. Membrane Associated Carbonic Anhydrase IV (CA IV): A Personal and Historical Perspective
Abdul Waheed, William S. Sly

10. Carbonic Anhydrase Expression in Kidney and Renal Cancer: Implications for Diagnosis and Treatment
Egbert Oosterwijk

11. Carbonic Anhydrase IX: Regulation and Role in Cancer
Martin Benej, Silvia Pastorekova, Jaromir Pastorek

12. Carbonic Anhydrase IX as an Imaging and Therapeutic Target for Tumors and Metastases
Narges K. Tafreshi, Mark C. Lloyd, Marilyn M. Bui, Robert J. Gillies, David L. Morse

13. Carbonic Anhydrase IX (CAIX) as a Mediator of Hypoxia-Induced Stress Response in Cancer Cells
Paul C. McDonald, Shoukat Dedhar

14. Carbonic Anhydrases and Brain pH in the Control of Neuronal Excitability
Eva Ruusuvuori, Kai Kaila

15. Carbonic Anhydrase Inhibitors Drug Design
Robert McKenna, Claudiu T. Supuran

16. Natural Products That Inhibit Carbonic Anhydrase
Sally-Ann Poulsen, Rohan A. Davis

17. Glaucoma and the Applications of Carbonic Anhydrase Inhibitors
Andrea Scozzafava, Claudiu T. Supuran

18. Carbonic Anhydrase Inhibitors and High Altitude Illnesses
Erik R. Swenson

19. Thermal-Stable Carbonic Anhydrases: A Structural Overview
Vincenzo Alterio, Simona Maria Monti, Giuseppina Simone

20. Carbonic Anhydrases in Industrial Applications
Javier M. González, S. Zoë Fisher

Keywords: Biomedicine, Gene Function, Protein Science, Biomedicine general