Evolution-adjusted Tumor Pathophysiology:

Part I. Introduction

1. Communication—Evolution—Pathophysiology: An Endogenous Conjunction—Instead of an Introduction
Albrecht Reichle

Part II. Combined Modularized Therapies for Metastatic Tumors: Pointing to Central Problems of Communication Among ‘Systems Participators’ in Tumors

2. Applied Systems Biology for the Control of Metastatic Cancer: Therapeutic Top-Down Strategy for Targeting the Tumors’ Normativity
A. Reichle, G. C. Hildebrandt

3. Targeting the Proangiogenic Network in Angiosarcomas: Biomodulatory Therapy
S. Singer, L. Größer

4. Long-Term Results of Combined Modularized, Immune-Modulatory, Angiostatic, and Antiinflammatory Therapy in Systemically Pre-Treated Multi-Systems Langerhans Cell Histiocytosis
A. Reichle, M. Vogelhuber, T. Vogt, L. Kunz-Schughart, T. Bretschneider, K. Bross, R. Andreesen

5. Redirecting and Modulating Rationalizations of Tumor-Immanent Normative Functions in Castration-Resistant Prostate Cancer
M. Vogelhuber, S. Feyerabend, A. Stenzl, T. Suedhoff, M. Schulze, J. Huebner, R. Oberneder, W. Wieland, S. Mueller, F. Eichhorn, H. Heinzer, K. Schmidt, M. Baier, A. Ruebel, K. Birkholz, A. Bakhshandeh-Bath, R. Andreesen, A. Reichle

Part III. Social Engineering: Biomodulation, Either Endogenously Initiated or by Implementation of Non-normative Boundary Conditions

6. Non-Hierarchically Organized Operations in Malignancies: Stromal Dysfunction Induces and Maintains Hematopoietic Malignancies
J. Grassinger, R. Schelker

7. Biomodulatory Therapy Approaches in Renal Clear Cell Carcinoma: A Perspective
Albrecht Reichle

8. Proteome Analysis Identified the PPARγ Ligand 15d-PGJ2 as a Novel Drug Inhibiting Melanoma Progression and Interfering with Tumor-Stroma Interaction
Verena Paulitschke, Silke Gruber, Elisabeth Hofstätter, Verena Haudek-Prinz, Philipp Klepeisz, Nikolaus Schicher, Constanze Jonak, Peter Petzelbauer, Hubert Pehamberger, Christopher Gerner, Rainer Kunstfeld

Part IV. The Tumors’ Normativity: Reconstructing and Operationalizing Starting Points for an Evolution Theory

9. The Philosophical Quest of a Cancer Cell: Redefining Existentialism
Ellora Sen

10. The Tumor’s Normativity: Normative Structures, Action Norms and Decision Maxims as Therapeutic Targets for Tumor Therapy
Albrecht Reichle, Joachim Hahn

11. Criticizable Claims for the Validity of Communication Acts in Biological Systems: Therapeutic Implications in Cancer
Albrecht Reichle, Christopher Gerner, Guy Haegeman

Part V. Evolution Theory

12. Evolution Theory: Its Practical Relevance for Understanding Tumor Development and Specifying Tumor Therapy
A. Reichle, G. C. Hildebrandt

13. Modularity, Subjectivity, Intersubjectivity and Normativity: Clinically Applicable Operative Benchmarks
Albrecht Reichle

14. Turning Upside Down the Mode of Science to Emphasize and Harness the Impact of Environmental Communication
Albrecht Reichle

Part VI. From Genome- or Organ-centric to Rationalization-centric Systematization of Tumors

15. Purposive-Rational Tumor Therapy: Exploiting the Tumor’s ‘Living World’ for Diversifying, Specifying and Personalizing Tumor Therapy
Albrecht Reichle, Gerhard C Hildebrandt

16. Including Rationalizations of Tumor-Associated Normative Notions in Pathophysiologic Considerations: Communication-Theoretical Implications
Albrecht Reichle

Part VII. Reconstruction of Tumor-Immanent Normative Functions, Structures and Decision Maxims (Hubs)

17. Bridging a Diagnostic and Therapeutic Gap: Selecting, Assessing and Categorizing, Tumor-associated Normative Notions
Albrecht Reichle

18. Personalizing Tumor Pathophysiology by Diagnosing Developmental Problems in Tumors with Imaging Techniques
Fabian Kiessling, Wiltrud Lederle

19. Biologic Memory: Induction by Metronomically Administered Combined Modularized Therapy
M. Vogelhuber, C. Hart, M. Grube, A. Reichle

Part VIII. The Tool of Rationalizations Constituting Tumor-Associated Normative Notions: The Non-Genomic Counterpart of the Tumor Genome and Therefore, an Important Therapeutic Target for Diversifying Palliative Care

20. Diversifying and Specifying Palliative Care for Patients with Metastatic Cancer by Therapeutic Implementation of Non-Normative Boundary Conditions
Albrecht Reichle, Gerhard C. Hildebrandt

21. Targeting a Hallmark of Cancer: Simultaneous Inflammation and Tumor Control for Palliative Care in Metastatic Cancer
J. Pfirstinger, A. Reichle, J. Grassinger

Part IX. Novel Clinical and Pharmaceutical Technology for Bioengineering Tumor Response

22. Combined Modularized Tumor Therapy—Tumor Biology—and Prognostic Factors: Bioengineering Tumor Response
Albrecht Reichle

Part X. Objectifying the Systems Objects’ Subjectivity in Biological Systems: A Novel Reification of the Scientific Picture About the ‘Objective’ World

23. The Subjectivity of Systems Objects as a Scientific Object
Albrecht Reichle

Keywords: Biomedicine, Cancer Research, Biomedicine general, Systems Biology, Pharmaceutical Sciences/Technology