Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases

1. Overview of Fibrillar and Oligomeric Assemblies of Amyloidogenic Proteins
Farid Rahimi, Gal Bitan

2. Pathologic Lesions in Alzheimer Disease and Other Neurodegenerative Diseases—Cellular and Molecular Components
Harry V. Vinters, Spencer Tung, Orestes E. Solis

3. Preparation and Structural Characterization of Pre-fibrillar Assemblies of Amyloidogenic Proteins
Anat Frydman-Marom, Yaron Bram, Ehud Gazit

4. Biological Targeting and Activity of Pre-fibrillar Aβ Assemblies
Kyle C. Wilcox, Jason Pitt, Adriano Sebollela, Helen Martirosova, Pascale N. Lacor, William L. Klein

5. The Role of Aβ and Tau Oligomers in the Pathogenesis of Alzheimer’s Disease
Kiran Bhaskar, Bruce T. Lamb

6. Oligomers of α-Synuclein in the Pathogenesis of Parkinson’s Disease
Dong-Pyo Hong, Wenbo Zhou, Aaron Santner, Vladimir N. Uversky

7. Cytotoxic Mechanisms of Islet Amyloid Polypeptide in the Pathogenesis of Type-2 Diabetes Mellitus (T2DM)
Theri Leica Degaki, Dahabada H. J. Lopes, Mari Cleide Sogayar

8. Protein Misfolding and Toxicity in Amyotrophic Lateral Sclerosis
Aaron Kerman, Avijit Chakrabartty

9. Structural Studies of Prion Proteins and Prions
Giuseppe Legname, Gabriele Giachin, Federico Benetti

10. Role of Prion Protein Oligomers in the Pathogenesis of Transmissible Spongiform Encephalopathies
Rodrigo Morales, Claudia A. Duran-Aniotz, Claudio Soto

11. When More Is Not Better: Expanded Polyglutamine Domains in Neurodegenerative Disease
Regina M. Murphy, Robert H. Walters, Matthew D. Tobelmann, Joseph P. Bernacki

12. Protein Misfolding and Toxicity in Dialysis-Related Amyloidosis
John P. Hodkinson, Alison E. Ashcroft, Sheena E. Radford

13. Transthyretin Aggregation and Toxicity
Maria João Saraiva, Isabel Santos Cardoso

14. Strategies for Inhibiting Protein Aggregation: Therapeutic Approaches to Protein-Aggregation Diseases
Jennifer D. Lanning, Stephen C. Meredith

Keywords: Biomedicine, Biomedicine general, Protein Science, Protein Structure, Neurosciences, Neurobiology, Pathology