Liver Metastasis: Biology and Clinical Management

1. Introduction
Pnina Brodt

2. Architectural and Functional Aspects of the Liver with Implications for Cancer Metastasis
Fernando Vidal-Vanaclocha

3. The Tumor Microenvironment at Different Stages of Hepatic Metastasis
Fernando Vidal-Vanaclocha

4. The Colorectal Cancer Initiating Cell: Markers and Their Role in Liver Metastasis
Margot Zöller, Thorsten Jung

5. Role of CXC Chemokines and Receptors in Liver Metastasis – Impact on Liver Resection-Induced Engraftment and Tumor Growth
Otto Kollmar, Michael D. Menger, Martin K. Schilling

6. Role of Inflammation in the Early Stages of Liver Metastasis
Jonathan Spicer, Pnina Brodt, Lorenzo Ferri

7. Signal Transduction in Tumor-Endothelial Cell Communication
Nicolas Porquet, Jacques Huot

8. Tumor Dormancy in Liver Metastasis: Clinical and Experimental Evidence and Implications for Treatment
Jason L. Townson, Ann F. Chambers

9. Role of the IGF-Axis in Liver Metastasis: Experimental and Clinical Evidence
Shun Li, Shoshana Yakar, Pnina Brodt

10. Breast Cancer Liver Metastasis
Sébastien Tabariès, Peter M. Siegel

11. Imaging of Hepatic Metastases
Mohamed El Khodary, Laurent Milot, Caroline Reinhold

12. Colorectal Carcinoma Liver Metastasis: Surgical Clinical Perspective
Adrian M. Fox, Steven Gallinger, Carol-Anne Moulton

13. Evaluation and Management of Liver Metastases from Non-gastrointestinal Cancer
Khaled Elgadi, Trevor Reichman, Sean P. Cleary

14. Proteomic Profiling of Hepatic Metastases: Paving the Way to Individualized Therapy
Alessandra Silvestri, Emanuel F. Petricoin, Lance A. Liotta, Mariaelena Pierobon

15. Targeting Angiogenesis in the Treatment of Hepatic Metastasis
Christina M. Edwards, J. Joshua Smith, Nipun B. Merchant, Alexander A. Parikh

16. Uveal Melanoma – A Paradigm of Site-Specific Liver Metastasis
Bruno F. Fernandes, Miguel N. Burnier

Keywords: Biomedicine, Cancer Research, Oncology, Surgical Oncology, Imaging / Radiology, Immunology