A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics

1. From Hypertension (+) to Asthma: Interactions with the Adenosine A3 Receptor from a Personal Perspective
John R. Fozard

2. Thermodynamic Analysis in Drug–Receptor Binding: The A3 Adenosine Receptor
Pier Andrea Borea, Stefania Gessi, Stefania Merighi, Katia Varani

3. Pharmacology and Molecular Biology of A3 Adenosine Receptors
Karl-Norbert Klotz

4. Regulation of Second Messenger Systems and Intracellular Pathways
Stefania Merighi, Carolina Simioni, Rob Lane, Adriaan P. Ijzerman

5. The Desensitisation as A3 Adenosine Receptor Regulation: Physiopathological Implications
Maria Letizia Trincavelli, Osele Ciampi, Claudia Martini

6. A3 Adenosine Receptor Agonists: History and Future Perspectives
Kenneth A. Jacobson, Zhan-Guo Gao, Dilip K. Tosh, Gangadhar J. Sanjayan, Sonia Castro

7. A3 Adenosine Receptor Antagonists: History and Future Perspectives
Pier Giovanni Baraldi, Romeo Romagnoli, Giulia Saponaro, Stefania Baraldi, Mojgan Aghazadeh Tabrizi, Delia Preti

8. Molecular Modeling and Reengineering of A3 Adenosine Receptors
Stefano Moro, Erika Morizzo, Kenneth A. Jacobson

9. Adenosine A3 Receptor Signaling in the Central Nervous System
Felicita Pedata, Anna Maria Pugliese, Ana M. Sebastião, Joaquim A. Ribeiro

10. Cardiovascular Biology of the A3 Adenosine Receptor
John P. Headrick, Jason N. Peart, Tina C. Wan, Wai-Meng Kwok, John A. Auchampach

11. A3 Adenosine Receptor in the Pulmonary System
Yifat Klein, Idit Matot

12. A3 Adenosine Receptor Regulation of Cells of the Immune System and Modulation of Inflammation
Stefania Gessi, Valerio Sacchetto, Eleonora Fogli, John Fozard

13. Adenosine A3 Receptors in Muscle Protection
Bruce T. Liang, Maria Urso, Edward Zambraski, Kenneth A. Jacobson

14. A3 Adenosine Receptors, HIF-1 Modulation and Atherosclerosis
Stefania Gessi, Stephen MacLennan, Edward Leung, Pier Andrea Borea

15. Rheumatoid Arthritis: History, Molecular Mechanisms and Therapeutic Applications
Pnina Fishman, Sara Bar-Yehuda

16. Agonists and Antagonists: Molecular Mechanisms and Therapeutic Applications
Pnina Fishman, Sara Bar-Yehuda, Katia Varani, Stefania Gessi, Stefania Merighi, Pier Andrea Borea

Keywords: Biomedicine, Pharmacology/Toxicology, Medicinal Chemistry, Cardiology, Pneumology/Respiratory System