New Trends in the Molecular and Biological Basis for Clinical Oncology

Part I. RTK-Related Signaling

1. HER2 Overexpression Attenuates the Antiproliferative Effect of Aromatase Inhibitor in MCF-7 Breast Cancer Cells Stably Expressing Aromatase
Incheol Shin, Todd Miller, E. Shizen Wang, Carlos L. Arteaga

2. Biomarker Research for Development of Molecular Target Agents
Kazuto Nishio, Tokuzo Arao

3. Epidermal Growth Factor (EGF) Receptor Kinase Activity is Required for Tumor Necrosis Factor (TNF)-? Mediated Intestinal Epithelial Survival
Toshimitsu Yamaoka, D. Brent Polk, Tohru Ohmori, Sojiro Kusumoto, Tomohide Sugiyama, Takao Shirai, Masanao Nakashima, Kentaro Okuda, Takashi Hirose, Tsukasa Ohnishi, Naoya Horichi, Mitsuru Adachi

4. A Molecular Mechanism of Diminished Binding Activity between 15 bp Deletion Mutant EGFR and c-Cbl Ubiquitin Ligase
Tohru Ohmori, Takamichi Hosaka, Tomoko Kanome, Fumiko Inoue, Koichi Ando, Takashi Hirose, Tsuyoki Kadofuku, Mitsuru Adachi

Part II. Inflammation, Angiogenesis, and Tumor Progression

5. TGF?-Mediated Epithelial Mesenchymal Transition and Metastasis in Skin and Head-and-Neck Cancer
Sophia Bornstein, Gang-Wen Han, Kristina Hoot, Shi-Long Lu, Xiao-Jing Wang

6. TGF-? and Tumor Progression Mediated by Reactive Oxygen Species
Kiyoshi Nose, Tadashi Sugimoto, Masami Wakamatsu, Fumihiro Ishikawa, Motoko Shibanuma

7. Role of MT1-MMP in Tumor-Stromal Interaction
Motoharu Seiki

8. Role of Proinflammatory Prostaglandin E2 in Bladder Tumor Progression
Shuntaro Hara

Part III. Biomarkers for Clinical Oncology

9. Molecular Biomarker for Lung Cancer
Hsuan-Yu Chen, Pan-Chyr Yang

10. Screening of Biomarker for Oral Squamous Cell Carcinoma Correlating with Clinicopathological Findings Using by Laser Microdissection and cDNA Microarray
Tarou Irié, Gou Yamamoto, Tomohide Isobe, Taku Matsunaga, Tetsuhiko Tachikawa

11. Biomarkers for Clinical Oncology
Yasutsuna Sasaki

12. Genome-Wide cDNA Microarray Screening of Gene Expression Profiles Correlated with Resistance to Anti-Cancer Drug Treatment and Radiation in Oral Squamous Cell Carcinoma
Satoru Shintani

Part IV. Poster Session

13. Drug Accumulation and Efflux Do not Contribute to Acquired Gefitinib Resistance
Sojiro Kusumoto, Tomohide Sugiyama, Masanao Nakashima, Toshimitsu Yamaoka, Takashi Hirose, Tsukasa Ohnishi, Naoya Horichi, Mitsuru Adachi, Kazuto Nishio, Nagahiro Saijo, Toshio Kuroki, Tohru Ohmori

14. Difference of EGFR-Binding Proteins between Wild Type and Mutant EGFR
Tsuyoki Kadofuku, Tomoko Kanome, Kazuto Nishio, Toshio Kuroki, Tohru Ohmori

15. Competitive Nuclear Export of Cyclin D1 and Hic-5 Regulates Anchorage-Dependence of Cell Growth and Survival
Kazunori Mori, Yukiko Oshima, Kiyoshi Nose, Motoko Shibanuma

16. Induction of Matrix Metalloprotease Gene Expression in an Endothelial Cell Line by Direct Interaction with Malignant Cells
Kiyoshi Egawa, Yuki Hasebe, Motoko Shibanuma, Kiyoshi Nose

17. Expression of Rad21 Cleaved Products in Oral Epithelium
Gou Yamamoto, Taku Matsunaga, Tomohide Isobe, Tarou Irie, Tetsuhiko Tachikawa

18. Telomerase-Specific Replication-Selective Virotherapy for Oral Squamous Cell Carcinoma Cell Lines
Yuji Kurihara, Yuichi Watanabe, Tom Kojima, Tatsuo Shirota, Masashi Hatori, Yasuo Urata, Toshiyoshi Fujiwara, Satoru Shintani

19. Hypoxia Induces Resistance to 5-Fluorouracil in Oral Cancer Cells Via G1 Phase Cell Cycle Arrest
Sayaka Yoshiba, Daisuke Ito, Tatsuhito Nagumo, Tatsuo Shirota, Masashi Hatori, Satoru Shintani

Keywords: Medicine & Public Health, Oncology