Innovative Medicine

Part I. Basic Research for Innovative Medicine

1. Diverting Glycolysis to Combat Oxidative Stress
Edouard Mullarky, Lewis C. Cantley

2. Metabolic Regulation by Nuclear Receptors
Sihao Liu, Michael Downes, Ronald M. Evans

3. Fighting Fire with Fire in Cancer
Thorsten Berger, Mary E. Saunders, Tak W. Mak

4. Linear Polyubiquitination: A Crucial Regulator of NF-κB Activation
Kazuhiro Iwai

5. VCP, a Major ATPase in the Cells, as a Novel Drug Target for Currently Incurable Disorders
Akira Kakizuka

6. Roles of E-cadherin in Hepatocarcinogenesis
Shin Maeda, Hayato Nakagawa

7. The Hippo Signaling Pathway: A Candidate New Drug Target for Malignant Tumors
Miki Nishio, Hiroki Goto, Miki Suzuki, Aya Fujimoto, Koshi Mimori, Akira Suzuki

8. Inhibitory Immunoreceptors on Mast Cells in Allergy and Inflammation
Akira Shibuya, Chigusa Nakahashi-Oda, Satoko Tahara-Hanaoka

9. Doxycycline-Inducible Autoimmune Blistering Skin Disease Model
Wataru Nishie, Hiroshi Shimizu

10. T Cell Senescence and Autoimmunity
Nagahiro Minato

Part II. Translational Research for Innovative Medicine

11. IL-6: A New Era for the Treatment of Autoimmune Inflammatory Diseases
Tadamitsu Kishimoto, Sujin Kang, Toshio Tanaka

12. Pathogenesis of Non-alcoholic Steatohepatitis and Its Potential Therapeutic Strategies
Yoshihiro Ogawa, Takayoshi Suganami, Michiko Itoh, Miyako Tanaka

13. Multifaceted Translational Approach to Major Mental Illness
Akira Sawa

14. Translational Research of Leptin in Lipodystrophy and Its Related Diseases
Ken Ebihara, Kazuwa Nakao

15. Translational Research of the Activation of the C-Type Natriuretic Peptide (CNP)-Guanylyl Cyclase-B Pathway for Skeletal Dysplasia
Akihiro Yasoda, Kazuwa Nakao

16. Clarity and Challenges in Tissue Fibrosis
Scott L. Friedman

17. TRP Channels: Their Function and Potentiality as Drug Targets
Motohiro Nishida, Koichiro Kuwahara, Daisuke Kozai, Reiko Sakaguchi, Yasuo Mori

18. Autophagic Cell Death and Cancer Chemotherapeutics
Shigeomi Shimizu

19. Adrenomedullin as a Potential Therapeutic Agent for Refractory Ulcerative Colitis
Kazuo Kitamura, Shinya Ashizuka, Haruhiko Inatsu, Toshihiro Kita

20. RNA Activation
X. Y. Zhao, J. Voutila, Nagy A. Habib, Vikash Reebye

Part III. New Technology for Innovative Medicine

21. Proceedings of the Uehara Memorial Foundation. Innovative Medicine: Basic Research and Development. Cardiac Reprogramming for Heart Repair
Masaki Ieda

22. Development of a New In Vivo Optical Probe for Biological Diagnosis and Therapy
Michitaka Ozaki, Takeaki Ozawa, Yuma Yamada

23. Introduction of Mesenchymal Stem Cells for Liver Surgery (Hepatectomy and Transplantation)
Shinji Uemoto, Yasuhiro Fujimoto, Takumi Teratani, Hiroyuki Kanazawa, Junji Iwasaki, Zhao Xiangdong, Yuki Masano, Shintaro Yagi, Koichiro Hata, Eiji Kobayashi

24. Synaptic and Axonal Plasticity Induction in the Human Cerebral Cortex
Yoshikazu Ugawa

25. TIM-3 Is a Novel Therapeutic Target for Eradicating Acute Myelogenous Leukemia Stem Cells
Koichi Akashi

26. TGF-β LAP Degradation Products, a Novel Biomarker and Promising Therapeutic Target for Liver Fibrogenesis
Mitsuko Hara, Tomokazu Matsuura, Soichi Kojima

27. Cell-Based Regenerative Therapy for Liver Disease
Kenichi Horisawa, Atsushi Suzuki

Keywords: Biomedicine, Molecular Medicine, Immunology, Cell Biology