Immunotherapy of Cancer

Part I. Overview, History, Classification

1. Overview of Current Cancer Immunotherapy
Yoshiyuki Yamaguchi

Part II. BRMs and Crude Agents

2. Bacterial Preparations
Junichi Sakamoto, Michitaka Honda, Toru Aoyama

3. Polysaccharides
Yasuyuki Sugiyama

4. BCG
Yoichi Mizutani

Part III. Adoptive Cell Therapy

5. αβ-T Cells
Atsushi Aruga

6. NKT Cell-Based Immunotherapy
Shinichiro Motohashi

7. Natural Killer Cells
Satoshi Kokura

8. γδ T Cell-Based Cancer Immunotherapy
Hirokazu Matsushita, Kazuhiro Kakimi

9. Genetically Engineered T Cells
Hiroaki Ikeda

Part IV. Vaccine Therapy

10. Peptide Vaccine
Koji Kono

11. Personalized Peptide Vaccine
Masanori Noguchi

12. WT1 Peptide Vaccine for the Treatment of Malignancies: Its Development, Recent Progress, and Future Perspectives
Yoshihiro Oka, Akihiro Tsuboi, Hiroko Nakajima, Fumihiro Fujiki, Sumiyuki Nishida, Soyoko Morimoto, Jun Nakata, Yoshiki Nakae, Satoshi Takashima, Naoya Tatsumi, Naoki Hosen, Yusuke Oji, Haruo Sugiyama

13. Protein Vaccine
Shinichi Kageyama

14. Dendritic Cell-Based Vaccine for Cancer
Masato Okamoto

Part V. Immunoadjuvants

15. CpG Motif
Masahiro Katsuda, Hiroki Yamaue

16. Pattern Recognition by Dendritic Cells and Its Application to Vaccine Adjuvant for Antitumor Immunotherapy
Tsukasa Seya, Masahiro Azuma, Misako Matsumoto

17. Novel Adjuvants
Burcu Temizoz, Etsushi Kuroda, Kouji Kobiyama, Taiki Aoshi, Ken J. Ishii

Part VI. Immunocheckpoints

18. Anti-CTLA-4 Ab
Takuto Tokudome

19. Anti-PD-1 and Anti-PD-L1 mAbs
Yoshimasa Tanaka, Craig T. Morita, Haruki Okamura

20. Novel Targets of Immune Inhibitory and Stimulatory Co-signals
Koji Tamada

Part VII. Regulation of Immunosuppression

21. Regulatory T Cells
Hideya Onishi, Takashi Morisaki, Mitsuo Katano

22. MDSC: Myeloid-Derived Suppressor Cells
Masahiko Shibata, Kenji Gonda, Seiichi Takenoshita

Part VIII. Immune-Related Response Criteria and Guidance for Clinical Trials

23. Immune-Related Response Criteria and Guidance for Clinical Trials
Hiroyuki Suzuki

Part IX. Personalized Immunotherapy

24. Personalized Cancer Immunotherapy: Immune Biomarkers and Combination Immunotherapy
Yutaka Kawakami, Boryana Popivanova, Sunthamala Nuchsupha, Taeko Hayakawa, Kenta Nakamura, Haruna Nagumo, Ikumi Katano, Tomonari Kinoshita, Kinya Tsubota, Hajime Kamijuku, Naoshi Kawamura, Junichiro Miyazaki, Ryosuke Satomi, Juri Sugiyama, Hiroshi Nishio, Shinobu Noji, Chie Kudo-Saito, Nobuo Tsukamoto, Toshiharu Sakurai, Tomonobu Fujita, Tomonori Yaguchi

Keywords: Medicine & Public Health, Oncology, Cancer Research, Immunology