Etiology and Morphogenesis of Congenital Heart Disease

Part I. From Molecular Mechanism to Intervention for Congenital Heart Diseases, Now and the Future

1. Reprogramming Approaches to Cardiovascular Disease: From Developmental Biology to Regenerative Medicine
Deepak Srivastava

2. The Arterial Epicardium: A Developmental Approach to Cardiac Disease and Repair
Adriana C. Gittenberger-de Groot, E. M. Winter, M. J. Goumans, M. M. Bartelings, R. E. Poelmann

3. Cell Sheet Tissue Engineering for Heart Failure
Hidekazu Sekine, Tatsuya Shimizu, Teruo Okano

4. Future Treatment of Heart Failure Using Human iPSC-Derived Cardiomyocytes
Shugo Tohyama, Keiichi Fukuda

5. Congenital Heart Disease: In Search of Remedial Etiologies
Roger R. Markwald, Shibnath Ghatak, Suniti Misra, Ricardo A. Moreno-Rodríguez, Yukiko Sugi, Russell A. Norris

Part II. Left-Right Axis and Heterotaxy Syndrome

6. Left-Right Asymmetry and Human Heterotaxy Syndrome
Isao Shiraishi

7. Roles of Motile and Immotile Cilia in Left-Right Symmetry Breaking
Hiroshi Hamada

8. Role of Cilia and Left-Right Patterning in Congenital Heart Disease
Nikolai Klena, George Gabriel, Xiaoqin Liu, Hisato Yagi, You Li, Yu Chen, Maliha Zahid, Kimimasa Tobita, Linda Leatherbury, Gregory Pazour, Cecilia W. Lo

9. Pulmonary Arterial Hypertension in Patients with Heterotaxy/Polysplenia Syndrome
Akimichi Shibata, Keiko Uchida, Jun Maeda, Hiroyuki Yamagishi

Part III. Cardiomyocyte and Myocardial Development

10. Single-Cell Expression Analyses of Embryonic Cardiac Progenitor Cells
Kenta Yashiro, Ken Suzuki

11. Meis1 Regulates Postnatal Cardiomyocyte Cell Cycle Arrest
Shalini A. Muralidhar, Hesham A. Sadek

12. Intercellular Signaling in Cardiac Development and Disease: The NOTCH pathway
Guillermo Luxán, Gaetano D’Amato, José Luis Pompa

13. The Epicardium in Ventricular Septation During Evolution and Development
Robert E. Poelmann, Bjarke Jensen, Margot M. Bartelings, Michael K. Richardson, Adriana C. Gittenberger-de Groot

14. S1P-S1p2 Signaling in Cardiac Precursor Cells Migration
Hajime Fukui, Shigetomo Fukuhara, Naoki Mochizuki

15. Myogenic Progenitor Cell Differentiation Is Dependent on Modulation of Mitochondrial Biogenesis through Autophagy
Yoshimi Hiraumi, Chengqun Huang, Allen M. Andres, Ying Xiong, Jennifer Ramil, Roberta A. Gottlieb

16. The Role of the Thyroid in the Developing Heart
Kazuhiro Maeda, Sachiko Miyagawa-Tomita, Toshio Nakanishi

Part IV. Valve Development and Diseases

17. Atrioventricular Valve Abnormalities: From Molecular Mechanisms Underlying Morphogenesis to Clinical Perspective
Kei Inai

18. Molecular Mechanisms of Heart Valve Development and Disease
M. Victoria Gomez Stallons, Elaine E. Wirrig-Schwendeman, Ming Fang, Jonathan D. Cheek, Christina M. Alfieri, Robert B. Hinton, Katherine E. Yutzey

19. A Novel Role for Endocardium in Perinatal Valve Development: Lessons Learned from Tissue-Specific Gene Deletion of the Tie1 Receptor Tyrosine Kinase
Xianghu Qu, H. Scott Baldwin

20. The Role of the Epicardium in the Formation of the Cardiac Valves in the Mouse
Marie M. Lockhart, Maurice Hoff, Andy Wessels

21. TMEM100: A Novel Intracellular Transmembrane Protein Essential for Vascular Development and Cardiac Morphogenesis
Ken Mizuta, Masahide Sakabe, Satoshi Somekawa, Yoshihiko Saito, Osamu Nakagawa

22. The Role of Cell Autonomous Signaling by BMP in Endocardial Cushion Cells in AV Valvuloseptal Morphogenesis
Yukiko Sugi, Bin Zhou, Kei Inai, Yuji Mishina, Jessica L. Burnside

Part V. The Second Heart Field and Outflow Tract

23. Properties of Cardiac Progenitor Cells in the Second Heart Field
Alexandre Francou, Robert G. Kelly

24. Nodal Signaling and Congenital Heart Defects
Ralston M. Barnes, Brian L. Black

25. Utilizing Zebrafish to Understand Second Heart Field Development
H. G. Knight, Deborah Yelon

26. A History and Interaction of Outflow Progenitor Cells Implicated in “Takao Syndrome”
Hiroyuki Yamagishi, Kazuki Kodo, Jun Maeda, Keiko Uchida, Takatoshi Tsuchihashi, Akimichi Shibata, Reina Ishizaki, Chihiro Yamagishi, Deepak Srivastava

27. The Loss of Foxc2 Expression in the Outflow Tract Links the Interrupted Arch in the Conditional Foxc2 Knockout Mouse
Mohammad Khaja Mafij Uddin, Wataru Kimura, Mohammed Badrul Amin, Kasumi Nakamura, Mohammod Johirul Islam, Hiroyuki Yamagishi, Naoyuki Miura

28. Modification of Cardiac Phenotype in Tbx1 Hypomorphic Mice
Takatoshi Tsuchihashi, Reina Ishizaki, Jun Maeda, Akimichi Shibata, Keiko Uchida, Deepak Srivastava, Hiroyuki Yamagishi

Part VI. Vascular Development and Diseases

29. Extracellular Matrix Remodeling in Vascular Development and Disease
Kyoko Imanaka-Yoshida

30. The “Cardiac Neural Crest” Concept Revisited
Sachiko Miyagawa-Tomita, Yuichiro Arima, Hiroki Kurihara

31. Roles of Endothelial Hrt Genes for Vascular Development
Masahide Sakabe, Takashi Morioka, Hiroshi Kimura, Osamu Nakagawa

32. Inositol Trisphosphate Receptors in the Vascular Development
Keiko Uchida, Maki Nakazawa, Chihiro Yamagishi, Katsuhiko Mikoshiba, Hiroyuki Yamagishi

33. Tissue Remodeling in Vascular Wall in Kawasaki Disease-Related Vasculitis Model Mice
Yukako Yoshikane, Mitsuhisa Koga, Tamaki Cho, Kyoko Imanaka-Yoshida, Yumi Yamamoto, Junichi Hashimoto, Hiroki Aoki, Koichi Yoshimura, Shinichi Hirose

Part VII. Ductus Arteriosus

34. Progerin Expression during Normal Closure of the Human Ductus Arteriosus: A Case of Premature Ageing?
Adriana C. Gittenberger-de Groot, Regina Bokenkamp, Vered Raz, Conny Munsteren, Robert E. Poelmann, Nimrat Grewal, Marco C. DeRuiter

35. The Multiple Roles of Prostaglandin E2 in the Regulation of the Ductus Arteriosus
Utako Yokoyama, Susumu Minamisawa, Yoshihiro Ishikawa

36. Developmental Differences in the Maturation of Sarcoplasmic Reticulum and Contractile Proteins in Large Blood Vessels Influence Their Contractility
Emiko Hayama, Toshio Nakanishi

37. Fetal and Neonatal Ductus Arteriosus Is Regulated with ATP-Sensitive Potassium Channel
Kazuo Momma, Mika Monma, Katsuaki Toyoshima, Emiko Hayama, Toshio Nakanishi

Part VIII. Conduction System and Arrhythmia

38. Regulation of Vertebrate Conduction System Development
Jan Hendrik Weerd, Vincent M. Christoffels

39. Cardiac Pacemaker Development from a Tertiary Heart Field
Michael Bressan, Gary Liu, Jonathan D. Louie, Takashi Mikawa

40. Endothelin Receptor Type A-Expressing Cell Population in the Inflow Tract Contributes to Chamber Formation
Rieko Asai, Yuichiro Arima, Daiki Seya, Ki-Sung Kim, Yumiko Kawamura, Yukiko Kurihara, Sachiko Miyagawa-Tomita, Hiroki Kurihara

41. Specific Isolation of HCN4-Positive Cardiac Pacemaking Cells Derived from Embryonic Stem Cells
Kumi Morikawa, Yasuaki Shirayoshi, Ichiro Hisatome

Part IX. Current Molecular Mechanism in Cardiovascular Development

42. Combinatorial Functions of Transcription Factors and Epigenetic Factors in Heart Development and Disease
Kazuko Koshiba-Takeuchi, Yuika Morita, Ryo Nakamura, Jun K. Takeuchi

43. Pcgf5 Contributes to PRC1 (Polycomb Repressive Complex 1) in Developing Cardiac Cells
Manabu Shirai, Yoshihiro Takihara, Takayuki Morisaki

44. Noncoding RNAs in Cardiovascular Disease
Masaharu Kataoka, Da-Zhi Wang

Part X. iPS Cells and Regeneration in Congenital Heart Diseases

45. Human Pluripotent Stem Cells to Model Congenital Heart Disease
Seema Mital

46. Engineered Cardiac Tissues Generated from Immature Cardiac and Stem Cell-Derived Cells: Multiple Approaches and Outcomes
Bradley B. Keller, Fei Ye, Fangping Yuan, Hiren Trada, Joseph P. Tinney, Kevin M. Walsh, Hidetoshi Masumoto

47. Dissecting the Left Heart Hypoplasia by Pluripotent Stem Cells
Junko Kobayashi, Shunji Sano, Hidemasa Oh

48. Lentiviral Gene Transfer to iPS Cells: Toward the Cardiomyocyte Differentiation of Pompe Disease-Specific iPS Cells
Yohei Sato, Takashi Higuchi, Hiroshi Kobayashi, Susumu Minamisawa, Hiroyuki Ida, Toya Ohashi

49. Molecular Analysis of Long-Term Cultured Cardiac Stem Cells for Cardiac Regeneration
Nanako Kawaguchi, Yohtaroh Takagaki, Rumiko Matsuoka, Toshio Nakanishi

50. Minor Contribution of Cardiac Progenitor Cells in Neonatal Heart Regeneration
Wataru Kimura, Shalini A. Muralidhar, SuWannee Thet

Part XI. Current Genetics in Congenital Heart Diseases

51. Genetic Discovery for Congenital Heart Defects
Bruce D. Gelb

52. Evidence That Deletion of ETS-1, a Gene in the Jacobsen Syndrome (11q-) Cardiac Critical Region, Causes Congenital Heart Defects through Impaired Cardiac Neural Crest Cell Function
Maoqing Ye, Yan Yin, Kazumi Fukatsu, Paul Grossfeld

53. Notch Signaling in Aortic Valve Development and Disease
Vidu Garg

54. To Detect and Explore Mechanism of CITED2 Mutation and Methylation in Children with Congenital Heart Disease
Wu Xiaoyun, Xu Min, Yang Xiaofei, Hu Jihua, Tian Jie

Keywords: Medicine & Public Health, Cardiology, Pediatric Surgery, Embryology, Pediatrics