Kataoka, Kazunori

Non-viral Gene Therapy

Kataoka, Kazunori - Non-viral Gene Therapy, ebook


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ISBN: 9784431278795
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Table of contents

1..Molecules for Gene Therapy

1. Recent Progress in Non-viral Gene Delivery
Christine C. Conwell, Leaf Huang

2. Physical Chemistry of DNA-Carrier Complexes
Kenichi Yoshikawa, Yuko Yoshikawa

3. Liposomes
Kazuo Maruyama

4. Polymeric Gene Carriers
Tomoko Hashimoto, Tetsuji Yamaoka

5. Development of a Supramolecular Nanocarrier for Gene Delivery Based on Cationic Block Copolymers
Yuichi Yamasaki, Woo-Dong Jang, Nobuhiro Nishiyama, Naoki Kanayama, Kazunori Kataoka

6. Chitosan
Mayu Hashimoto, Zhihong Yang, Yohei Koya, Toshinori Sato

7. Dendrimers as DNA Carriers
Hidetoshi Arima

8. Use of Synthetic Peptides for Non-viral Gene Delivery
Takuro Niidome, Yoshiki Katayama

9. An Oligonucleotide Carrier Based on ß-1,3-Glucans
Kazuo Sakurai, Seiji Shinkai

10. Biological and Chemical Hybrid Vectors
Mahito Nakanishi

2..Controlled Gene Delivery

11. Pharmacokinetics of Gene Delivery in Cells
Hidetaka Akita, Ikramy A. Khalil, Kentaro Kogure, Hideyoshi Harashima

12. Active DNA Release from Complexes
Takeshi Nagasaki

13. Controlled Release of DNA Using Thermoresponsive Polymers
Masayuki Yokoyama

14. Active Transport of Exogenous Genes into the Nucleus
Takeshi Kawazu, Takeshi Nagasaki

15. Controlled Intracellular Localization of Oligonucleotides by Chemical Conjugation
Takanori Kubo, Rumiana Bakalova, Zhivko Zhelev, Hideki Ohba, Masayuki Fujii

16. Functional Nucleotide Sequences Capable of Promoting Non-viral Genetic Transfer
Osam Mazda, Tsunao Kishida

17. Shielding of Cationic Charge of the DNA Complex to Avoid Nonspecific Interactions for In Vivo Gene Delivery
Yoshiyuki Koyama

18. In Vivo Gene Transfer by Ligand-Modified Gene Carriers
Shigeru Kawakami, Mitsuru Hashida

19. Optimizing Polyplexes into Synthetic Viruses for Tumor-Targeted Gene Therapy
Ernst Wagner, Julia Kloeckner, Manfred Ogris

20. Gene Transfer and Target Diseases
Mariko Harada-Shiba

21. Clinical Trials Using Non-viral Gene Delivery Systems
Hironobu Yanagie

3..Current Protocols of Gene Delivery

22. Evaluation of Size and Zeta Potential of DNA/Carrier Complexes
Yoshiyuki Hattori, Mitsuru Hashida

23. Observation of DNA/Carrier Complexes Under Fluorescence Microscopy
Tomoko Ito, Yoshiyuki Koyama, Kenichi Yoshikawa

24. Synthesis of Chemically Modified Chitosan and a Study of Its Gene Transfection Efficiency
Taku Satoh

25. Newly Designed DNA Fragments for Gene Correction
Hiroyuki Kamiya, Hiroyuki Tsuchiya, Hideyoshi Harashima

26. Evaluation of Gene Expression In Vivo After Intravenous and Intraportal Administration of Lipoplexes
Tatsuya Okuda, Shigeru Kawakami, Mitsuru Hashida

27. Evaluation by Southern Blot Hybridization of DNA Administered with a Gene Carrier to Organs
Takahito Kawano, Takuro Niidome

28. Evaluation of the Immune Response After Administration of Plasmid DNA-Non-viral Vector Complexes
Fuminori Sakurai, Yoshinobu Takakura, Mitsuru Hashida

29. Gateway RNAi
Knut R. Madden, Adam N. Harris, Jennifer M. Kilzer, Heidi L. Welchin, Peter J. Welch

4..Design of Genes Based on Current RNA Technology

30. Design of Intracellularly Active Ribozymes and siRNAs
Makoto Miyagishi, Kazunari Taira

31. RNAi-Based Inhibition Specific for Mutant Alleles in Autosomal Dominant Diseases: Sequence-Dependent and -Independent Discrimination of Mutant and Wild-Type Alleles by siRNA
Takanori Yokota

32. In Vivo RNA Interference: Another Tool in the Box?
Silvère Petit, Emmanuel Valentin, Kader Thiam

33. Suppression of Gene Expression via Chromatin Remodeling and the siRNA-Induced Silencing of Transcription
Hiroaki Kawasaki, Yoko Fukuda, Kazunari Taira, Kevin V. Morris

34. Intracellular Delivery of Nucleic Acids: Differences Between Transfection and siFection Reflect Differences Between DNA and RNA, and Between Oligodeoxynucleotides and Oligonucleotides
Michael Keller, Andrew D. Miller

35. In Vivo Antitumor Activity of a New Cationic Liposome siRNA Complex
Junichi Yano, Gerald E. Smyth, Kazuko Hirabayashi, Tadaaki Ohgi

36. Enhancing RNAi with Synthetic RNA Duplexes
Dong-Ho Kim, Mark A. Behlke, Scott D. Rose, Mi-Sook Chang, Sangdun Choi, John J. Rossi


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Keywords: SCIENCE / Life Sciences / Biology / General SCI008000

Publication year
Natural Sciences

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