Natural Compounds as Drugs

1. Activation of fungal silent gene clusters: A new avenue to drug discovery
Axel A. Brakhage, Julia Schuemann, Sebastian Bergmann, Kirstin Scherlach, Volker Schroeckh, Christian Hertweck

2. Total synthesis studies on macrocyclic pipecolic acid natural products: FK506, the antascomicins and rapamycin
Matthew L. Maddess, Miles N. Tackett, Steven V. Ley

3. Application of natural product-inspired diversity-oriented synthesis to drug discovery
Lisa A. Marcaurelle, Charles W. Johannes

4. Cheminformatics analysis of natural products: Lessons from nature inspiring the design of new drugs
Peter Ertl, Ansgar Schuffenhauer

5. Chemical-genetic approaches for exploring the mode of action of natural products
Andres Lopez, Ainslie B. Parsons, Corey Nislow, Guri Giaever, Charles Boone

6. Epothilones as lead structures for new anticancer drugs — pharmacology, fermentation, and structure-activity-relationships
Karl-Heinz Altmann, Klaus Memmert

7. Histone deacetylase inhibitors from microorganisms: the Astellas experience
Yuhta Masuoka, Nobuaki Shindoh, Noriaki Inamura

8. Ascomycete derivative to MS therapeutic: S1P receptor modulator FTY720
Peter C. Hiestand, Martin Rausch, Daniela Piani Meier, Carolyn A. Foster

9. Artemisinin — an innovative cornerstone for anti-malaria therapy
Kuhn Thomas, Wang Ying

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Keywords: TECHNOLOGY & ENGINEERING / Biomedical TEC059000