Molecular, Clinical and Environmental Toxicology

1. Historical milestones and discoveries that shaped the toxicology sciences
Antoinette N. Hayes, Steven G. Gilbert

2. Physiologically based toxicokinetic models and their application in human exposure and internal dose assessment
David Kim, Leena A. Nylander-French

3. The role of biotransformation and bioactivation in toxicity
Wolfgang Dekant

4. Genotoxicity: damage to DNA and its consequences
David H. Phillips, Volker M. Arlt

5. Role of DNA repair in the protection against genotoxic stress
Ulrike Camenisch, Hanspeter Naegeli

6. On the impact of the molecule structure in chemical carcinogenesis
Andreas Luch

7. Chemical induced alterations in p53 signaling
Johan Högberg, Ilona Silins, Ulla Stenius

8. Molecular pathways involved in cell death after chemically induced DNA damage
Roberto Sánchez-Olea, Mónica R. Calera, Alexei Degterev

9. The aryl hydrocarbon receptor at the crossroads of multiple signaling pathways
Ci Ma, Jennifer L. Marlowe, Alvaro Puga

10. Mapping the epigenome — impact for toxicology
Jennifer Marlowe, Soon-Siong Teo, Salah-Dine Chibout, François Pognan, Jonathan Moggs

11. Receptors mediating toxicity and their involvement in endocrine disruption
Joëlle Rüegg, Pauliina Penttinen-Damdimopoulou, Sari Mäkelä, Ingemar Pongratz, Jan-Åke Gustafsson

12. Toxicogenomics: transcription profiling for toxicology assessment
Tong Zhou, Jeff Chou, Paul B. Watkins, William K. Kaufmann

13. The role of toxicoproteomics in assessing organ specific toxicity
B. Alex Merrick, Frank A. Witzmann

14. High-throughput screening for analysis of in vitro toxicity
Willem G. E. J. Schoonen, Walter M. A. Westerink, G. Jean Horbach

Keywords: Biomedicine, Pharmacology/Toxicology