Systems Biological Approaches in Infectious Diseases

1. Systems biology and its impact on anti-infective drug development
Michael P. Stumpf, Brian D. Robertson, Ken Duncan, Douglas B. Young

2. Applications of transcriptional profiling in antibiotics discovery and development
Hans Peter Fischer, Christoph Freiberg

3. Chemical genetics: An evolving toolbox for target identification and lead optimization
Helena I. Boshoff, Cynthia S. Dowd

4. Proteomic profiling of cellular stresses in Bacillus subtilis reveals cellular networks and assists in elucidating antibiotic mechanisms of action
Julia E. Bandow, Michael Hecker

5. Elucidating the mode-of-action of compounds from metabolite profiling studies
Jesper Højer-Pedersen, Jørn Smedsgaard, Jens Nielsen

6. A subsystems-based approach to the identification of drug targets in bacterial pathogens
Andrei L. Osterman, Tadhg P. Begley

7. Metabolic control analysis to identify optimal drug targets
Jorrit J. Hornberg, Frank J. Bruggeman, Barbara M. Bakker, Hans V. Westerhoff

8. The protein network as a tool for finding novel drug targets
Michael Strong, David Eisenberg

9. Toxicogenomics applied to predictive and exploratory toxicology for the safety assessment of new chemical entities: a long road with deep potholes
François Pognan

10. Biological robustness in complex host-pathogen systems
Hiroaki Kitano

11. Toward whole cell modeling and simulation: Comprehensive functional genomics through the constraint-based approach
Andrew R. Joyce, Bernhard Ø. Palsson

12. Genomics of host-pathogen interactions
Dirk Schnappinger

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Keywords: TECHNOLOGY & ENGINEERING / Biomedical TEC059000