Imaging in Drug Discovery and Early Clinical Trials

1. The drug discovery process
Paul L. Herrling

2. Imaging modalities: principles and information content
Tobias Schaeffter

3. Magnetic resonance and fluorescence based molecular imaging technologies
David Sosnovik, Ralph Weissleder

4. Studying molecular and cellular processes in the intact organism
Olivier Gheysens, Sanjiv S. Gambhir

5. Disease phenotyping: structural and functional readouts
R. Mark Henkelman, X. Josette Chen, John G. Sled

6. Evaluation of drug candidates: Efficacy readouts during lead optimization
Markus Rudin, Nicolau Beckmann, Martin Rausch

7. Risk identification and management: MRI as a research tool in toxicology studies of new chemical entities
Mark W. Tengowski, John J. Kotyk

8. Pharmacokinetic studies with PET
Mats Bergström, Bengt Långström

9. Imaging bio-markers predictive of disease/therapy outcome: ischemic stroke and drug development
Janet C. Miller, A. Gregory Sorensen

10. Clinical drug evaluation using imaging readouts: regulatory perspectives
David S. Lester

DRM-restrictions

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Keywords: MEDICAL / Public Health MED078000