The Hereditary Basis of Rheumatic Diseases

A..Introduction

1. Genetics of joint inflammation — problems and possibilities
Rikard Holmdahl

B..Genetic studies on rheumatic diseases

2. The epidemiology of rheumatoid arthritis and the use of linkage and association studies to identify disease genes
Jane Worthington, Anne Barton, Sally L. John

3. Heterogeneity in rheumatoid arthritis based on expression analysis: towards personalised medicine
Cornelis L. Verweij, Tineke C. T. M. Pouw Kraan

4. Gene-based large scale LD-mapping of rheumatoid arthritis-associated genes
Ryo Yamada, Kazuhiko Yamamoto

C..Shared heredity of rheumatic diseases

5. Emerging relationships: rheumatoid arthritis and the PTPN22 associated autoimmune disorders
Peter K. Gregersen, Robert M. Plenge

6. Shared genes in rheumatic diseases, the role of PD1 and the RUNX genes in disease susceptibility
Marta E. Alarcón-Riquelme, Sergey V. Kozyrev

7. The role of B27 and other genes associated with ankylosing spondylitis
Joachim Sieper, Martin Rudwaleit

D..Tools for analysing complexity

8. Emerging tools for dissecting complex disease
Ulf D. Landegren

9. Expression analysis of rheumatic diseases, prospects and problems
Thomas Häupl, Andreas Grützkau, Joachim Grün, Andreas Radbruch, Gerd Burmester

10. The use of humanized MHC mouse strains for studies of rheumatic diseases
Kary A. Latham, Timothy D. Kayes, Zhaohui Qian, Edward F. Rosloniec

11. SKG mice, a monogenic model of autoimmune arthritis due to altered signal transduction in T-cells
Shimon Sakaguchi, Takeshi Takahashi, Hiroshi Hata, Hiroyuki Yoshitomi, Satoshi Tanaka, Keiji Hirota, Takashi Nomura, Noriko Sakaguchi

12. A genetic approach to select and validate new targets for treatment of rheumatic diseases
Peter J. Olofsson

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Keywords: MEDICAL / Public Health MED078000