Advances in Targeted Cancer Therapy

1. Dawn of a new era in molecular cancer therapeutics
Richard M. Schultz

2. Obtacles and opportunities in the clinical development of targeted therapeutics
Grace K. Dy, Alex A. Adjei

3. Tumor models for preclinical development of targeted agents
Beverly A. Teicher

4. Angiogenesis inhibitors: What is the clinical future?
Henk M. W. Verheul, Herbert M. Pinedo

5. Epidermal growth factor receptor (EGFR) inhibitors in cancer therapy
Fortunato Ciardiello, Ferdinando Vita

6. Cell survival signaling during apoptosis: Implications in drug resistance and anti-cancer therapeutic development
Grace Choy, Jun-Wei Liu, Dhyan Chandra, Dean G. Tang

7. Targeted histone deacetylase inhibition for cancer prevention and therapy
Carlo Palmieri, R. Charles Coombes, David M. Vigushin

8. Inhibitors of cyclin-dependent kinase modulators for cancer therapy
Adrian M. Senderowicz

9. Targeting cyclooxygenase-2 for cancer prevention and treatment
Stephen T. Gately

10. Antisense approaches in drug discovery and development
Elizabeth Rayburn, Wei Wang, Ruiwen Zhang, Hui Wang

11. Preclinical development of Alimta™ (Pemetrexed, LY231514), a multitargeted antifolate
Richard M. Schultz

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Keywords: TECHNOLOGY & ENGINEERING / Biomedical TEC059000