The Intervertebral Disc

Part I. Biomechanical and Molecular Studies of the Intervertebral Disc

1. Introduction to the Structure, Function, and Comparative Anatomy of the Vertebrae and the Intervertebral Disc
Irving M. Shapiro, Makarand V. Risbud

2. The Intervertebral Disc: Overview of Disc Mechanics
Daniel H. Cortes, Dawn M. Elliott

3. Development of the Intervertebral Disc
Megan K. Cox, Rosa Serra

4. Proteoglycans of the Intervertebral Disc
James Melrose, Peter Roughley

5. Collagen and Other Proteins of the Nucleus Pulposus, Annulus Fibrosus, and Cartilage End Plates
Fackson Mwale

6. Microenvironmental Control of Disc Cell Function: Influence of Hypoxia and Osmotic Pressure
Makarand V. Risbud, Irving M. Shapiro

7. The Effects of Mechanical Forces on Nucleus Pulposus and Annulus Fibrosus Cells
Jeffrey C. Lotz, Adam H. Hsieh

8. The Role of the ADAMTS Proteins in the Intervertebral Disc
Jason C. Ho, James Wylie, Suneel S. Apte

Part II. Intervertebral Disc Disease: Pathogenesis and Current Treatment Modalities

9. Epidemiology of Lumbar Disc Degeneration
Yue Wang, Michele C. Battié

10. Genetic Basis of Intervertebral Disc Degeneration
Anita Yee, Danny Chan

11. Pathogenesis of Intervertebral Disc Degeneration
Stephen M. Richardson, Anthony J. Freemont, Judith A. Hoyland

12. Imaging Modalities for Studying Disc Pathology
Ari Borthakur, Ravinder Reddy

13. Surgical Indications for Lumbar Degenerative Disease
Ravi R. Patel, Jeffrey A. Rihn, Ravi K. Ponnoppan, Todd J. Albert

14. Spinal Motion Restoration Devices for the Degenerative Disc
Daniel G. Kang, Melvin D. Helgeson, Alexander R. Vaccaro

15. The Nonsurgical Treatment of Back Pain
Isaac L. Moss, Howard S. An, Francis H. Shen, Zemin Li, Gunnar B. J. Andersson, Yejia Zhang

16. Back Pain and Disc Degeneration: Are They Really Linked?
Kjell Olmarker

17. Clinical Features and Pathobiology of Chordoma
John A. Abraham, Brian Neuman, Francis J. Hornicek

Part III. Models of Disc Disease and Biological Regeneration

18. Large Animal Models of Disc Degeneration
Shyam A. Patel, Christopher K. Kepler, Thomas P. Schaer, D. Greg Anderson

19. Intervertebral Disc Herniation: Pathophysiology and Emerging Therapies
Beth A. Winkelstein, Kyle D. Allen, Lori A. Setton

20. The Sand Rat (Psammomys obesus obesus) Model of Spontaneous, Age-Related Intervertebral Disc Degeneration
Helen E. Gruber, Edward N. Hanley

21. Use of Knockout and Transgenic Mouse Models in Disc Research
Laura Mangiavini, Rita Gerard-O’Riley, Ernestina Schipani

22. Intervertebral Disc Culture Models and Their Applications to Study Pathogenesis and Repair
Svenja Illien-Jünger, Benjamin A. Walter, Jillian E. Mayer, Andrew C. Hecht, James C. Iatridis

23. Use of Stem Cells for Regeneration of the Intervertebral Disc
Daisuke Sakai, Joji Mochida

24. Gene Therapy Approaches for Disc Regeneration
Zulma Gazit, Nadav Kimelman-Bleich, Olga Mizrahi, Dan Gazit

25. Enhancing Disc Repair by Growth Factors and Other Modalities
Won C. Bae, Koichi Masuda

26. Tissue Engineering of the Intervertebral Disc
Rita Kandel, Paul Santerre, Eric Massicotte, Mark Hurtig

Keywords: Medicine & Public Health, Surgical Orthopedics, Neurosurgery, Orthopedics