Botulinum Neurotoxins

1. Genetic Diversity Within Clostridium botulinum Serotypes, Botulinum Neurotoxin Gene Clusters and Toxin Subtypes
Karen K. Hill, Theresa J. Smith

2. Assembly and Function of the Botulinum Neurotoxin Progenitor Complex
Shenyan Gu, Rongsheng Jin

3. Uptake of Botulinum Neurotoxin in the Intestine
Yukako Fujinaga, Yo Sugawara, Takuhiro Matsumura

4. Double Receptor Anchorage of Botulinum Neurotoxins Accounts for their Exquisite Neurospecificity
Andreas Rummel

5. The Elusive Compass of Clostridial Neurotoxins: Deciding When and Where to Go?
Kinga Bercsenyi, Francesco Giribaldi, Giampietro Schiavo

6. Synchronized Chaperone Function of Botulinum Neurotoxin Domains Mediates Light Chain Translocation into Neurons
Audrey Fischer

7. Clostridial Neurotoxin Light Chains: Devices for SNARE Cleavage Mediated Blockade of Neurotransmission
Thomas Binz

8. Synaptic Vesicle Proteins: Targets and Routes for Botulinum Neurotoxins
Gudrun Ahnert-Hilger, Agnieszka Münster-Wandowski, Markus Höltje

9. Persistence of Botulinum Neurotoxin Inactivation of Nerve Function
Charles B. Shoemaker, George A. Oyler

10. Structure-Based Drug Discovery for Botulinum Neurotoxins
Subramanyam Swaminathan

11. Complexity of Botulinum Neurotoxins: Challenges for Detection Technology
Martin B. Dorner, K. Melanie Schulz, Skadi Kull, Brigitte G. Dorner

12. Progress in Cell Based Assays for Botulinum Neurotoxin Detection
Sabine Pellett

13. Transforming the Domain Structure of Botulinum Neurotoxins into Novel Therapeutics
John Chaddock

14. Botulinum Toxin: Application, Safety, and Limitations
Hans Bigalke

Keywords: Biomedicine, Pharmacology/Toxicology, Neurosciences