Histone Deacetylases: the Biology and Clinical Implication

1. K-Acetylation and Its Enzymes: Overview and New Developments
Juliette Adjo Aka, Go-Woon Kim, Xiang-Jiao Yang

2. The Biology of HDAC in Cancer: The Nuclear and Epigenetic Components
Astrid Hagelkruys, Anna Sawicka, Magdalena Rennmayr, Christian Seiser

3. Deacetylation of Nonhistone Proteins by HDACs and the Implications in Cancer
Lirong Peng, Edward Seto

4. The Biology and Therapeutic Implications of HDACs in the Heart
Timothy A. McKinsey

5. HDACs in Skeletal Muscle Remodeling and Neuromuscular Disease
Bryan J. Simmons, Todd J. Cohen, Richard Bedlack, Tso-Pang Yao

6. Rationale for HDAC Inhibitor Therapy in Autoimmunity and Transplantation
Wayne W. Hancock

7. The Role of Mammalian Sirtuins in the Regulation of Metabolism, Aging, and Longevity
Akiko Satoh, Liana Stein, Shin Imai

8. Mitochondrial Sirtuins in the Regulation of Mitochondrial Activity and Metabolic Adaptation
David B. Lombard, Daniel X. Tishkoff, Jianjun Bao

9. Characterization of Nuclear Sirtuins: Molecular Mechanisms and Physiological Relevance
Debra Toiber, Carlos Sebastian, Raul Mostoslavsky

10. Structural Biology of Human Metal-Dependent Histone Deacetylases
Matthieu Schapira

11. Sirtuin Modulators
Sumit S. Mahajan, Vid Leko, Julian A. Simon, Antonio Bedalov

Keywords: Biomedicine, Pharmacology/Toxicology, Biomedicine general, Posttranslational Modification, Protein Science, Laboratory Medicine, Gene Function