Transformative Concepts for Drug Design: Target Wrapping

1. Protein Cooperativity and Wrapping: Two Themes in the Transformative Platform of Molecular Targeted Therapy
Ariel Fernandez

2. Wrapping Defects and the Architecture of Soluble Proteins
Ariel Fernandez

3. Folding Cooperativity and the Wrapping of Intermediate States of Soluble Natural Proteins
Ariel Fernandez

4. Wrapping Deficiencies and De-wetting Patterns in Soluble Proteins: A Blueprint for Drug Design
Ariel Fernandez

5. Under-Wrapped Proteins in the Order–Disorder Twilight: Unraveling the Molecular Etiology of Aberrant Aggregation
Ariel Fernandez

6. Evolution of Protein Wrapping and Implications for the Drug Designer
Ariel Fernandez

7. Wrapping as a Selectivity Filter for Molecular Targeted Therapy: Preliminary Evidence
Ariel Fernandez

8. Re-engineering an Anticancer Drug to Make It Safer: Modifying Imatinib to Curb Its Side Effects
Ariel Fernandez

9. Wrapping Patterns as Universal Markers for Specificity in the Therapeutic Interference with Signaling Pathways
Ariel Fernandez

10. Fulfilling a Therapeutic Imperative in Cancer Treatment: Control of Multi-target Drug Impact
Ariel Fernandez

11. Inducing Folding By Crating the Target
Ariel Fernandez

12. Wrapper Drugs as Therapeutic Editors of Side Effects
Ariel Fernandez

13. Wrapper Drugs for Personalized Medicine
Ariel Fernandez

14. Last Frontier and Back to the Drawing Board: Protein–Water Interfacial Tension in Drug Design
Ariel Fernandez

Keywords: Engineering, Biomedical Engineering, Medicinal Chemistry, Biophysics and Biological Physics, Cancer Research