Synaptic Plasticity and the Mechanism of Alzheimer's Disease

1. Permanence of the Synapse and Molecular Instability
Marianne Renner, Antoine Triller

2. Cellular Biology of AMPA Receptor Trafficking and Synaptic Plasticity
José A. Esteban

3. Imaging of Experience-Dependent Structural Plasticity in the Mouse Neocortex in vivo
Antony Holtmaat, V. Paola, L. Wilbrecht, G. Knott

4. Synapse Loss, Synaptic Plasticity and the Postsynaptic Density
Morgan Sheng

5. Impact of Beta Amyloid on Excitatory Synaptic Transmission and Plasticity
Roberto Malinow, Helen Hsieh, Wei Wei

6. Quantitative Neuropathology in Alzheimer’s Mouse Models
Floyd E. Bloom

7. Multiple Levels of Synaptic Regulation by NMDA-type Glutamate Receptor in Normal and Disease States
Veronica A. Alvarez, Ganesh M. Shankar, Brenda L. Bloodgood, Dennis J. Selkoe, Bernardo L. Sabatini

8. Soluble Oligomers of the Amyloid ß-Protein: Impair Synaptic Plasticity and Behavior
Dennis J. Selkoe

9. Why Alzheimer’s is a Disease of Memory: Synaptic Targeting by Pathogenic Aß Oligomers (ADDLs)
WilliamL. Klein, Fernanda Felice, Pascale N. Lacor, Mary P. Lambert, Wei-Qin Zhao

10. Synaptic Transmission Dynamically Modulates Interstitial Fluid Amyloid-ß Levels
John R. Cirrito, Floy R. Stewart, Steven Mennerick, David M. Holtzman

11. Aß-Induced Toxicity Mediated by Caspase Cleavage of the Amyloid Precursor Protein (APP)
Edward H. Koo, Dale E. Bredesen

12. Long-Term Potentiation and Aß: Targeting Aß Species, Cellular Mechanisms and Putative Receptors
Michael J. Rowan, Igor Klyubin, William K. Cullen, NengWei Hu, Roger Anwyl

13. Genes, Synapses and Autism Spectrum Disorders
Thomas Bourgeron

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Keywords: TECHNOLOGY & ENGINEERING / Biomedical TEC059000