Telomeres and Telomerase in Ageing, Disease, and Cancer

Part I. Telomere Shortening and Ageing

1. Cellular versus Organismal Aging
Andrew Dillin, Jan Karlseder

2. Telomere-Induced Senescence of Primary Cells
Richard Allsopp

3. Telomeres, Senescence, Oxidative Stress, and Heterogeneity
João F. Passos, Glyn Nelson, Thomas Zglinicki

4. Initiation of Genomic Instability, Cellular Senescence, and Organismal Aging by Dysfunctional Telomeres
Sandy Chang

5. Telomerase Mutations and Premature Ageing in Humans
Hong-Yan Du, Monica Bessler, Philip J. Mason

Part II. Telomerase, Telomeres, and Stem Cell Aging

6. Mechanisms of Stem Cell Ageing
Amanda Waterstrat, Erin Oakley, Alison Miller, Carol Swiderski, Ying Liang, Gary Zant

7. Senescence Signatures of Human Hematopoietic Stem Cells
Stefan Zimmermann, Uwe M. Martens

8. Telomere Shortening Induces Cell Intrinsic Checkpoints and Environmental Alterations Limiting Adult Stem Cell Function
Luis Guachalla Gutierrez, Zhenyu Ju

9. p16INK4a and Stem Cell Ageing: A Telomere-Independent Process?
Norman E. Sharpless

10. Telomerase as a Potential Regulator of Tissue Progenitor Cells
Steven E. Artandi

Part III. Telomeres, DNA Damage and Cancer

11. Telomere Shortening and Telomerase Activation during Cancer Formation
K. Lenhard Rudolph

12. Telomere Binding Proteins and Disease
Maria A. Blasco

Part IV. Therapeutic Targets

13. Targeting Telomerase: Therapeutic Options for Cancer Treatment
W. Nicol Keith, Alan E. Bilsland

14. Werner Syndrome, Telomeres, and Stress Signaling: Implications for Future Therapies?
Terence Davis, David Kipling

DRM-restrictions

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Keywords: TECHNOLOGY & ENGINEERING / Biomedical TEC059000