Therapeutic Antibodies

1. Introduction

1. Historical Development of Monoclonal Antibody Therapeutics
A. Nissim, Y. Chernajovsky

2. Preclinical Safety Evaluation of Monoclonal Antibodies
C. M. Lynch, I. S. Grewal

2. Molecular Developments in Antibody Production

3. Engineering Antibodies for Stability and Efficient Folding
A. Honegger

4. Human Monoclonal Antibodies from Transgenic Mice
N. Lonberg

3. Antibodies to Cytokines

5. Anti-TNF Antibodies: Lessons from the Past, Roadmap for the Future
D. J. Shealy, S. Visvanathan

6. Therapeutic Anti-VEGF Antibodies
S. Lien, H. B. Lowman

7. Humanized Antihuman IL-6 Receptor Antibody, Tocilizumab
N. Nishimoto, T. Kishimoto

4. Antibodies to Cell Markers

8. Anti-CD20Monoclonal Antibody in Rheumatoid Arthritis and Systemic Lupus Erythematosus
F. Goldblatt, D. A. Isenberg

9. Herceptin
H. M. Shepard, P. Jin, D. J. Slamon, Z. Pirot, D. C. Maneval

10. The Use of CD3-Specific Antibodies in Autoimmune Diabetes: A Step Toward the Induction of Immune Tolerance in the Clinic
L. Chatenoud

11. Monoclonal Antibody Therapy for Prostate Cancer
A. Jakobovits

12. Anti-IgE and Other Antibody Targets in Asthma
J. Singh, M. Kraft

5. Development of Antibody-Based Cellular and Molecular Therapies

13. Cytokine, Chemokine, and Co-Stimulatory Fusion Proteins for the Immunotherapy of Solid Tumors
L. A. Khawli, P. Hu, A. L. Epstein

14. The T-Body Approach: Redirecting T Cells with Antibody Specificity
Z. Eshhar

15. Intracellular Antibodies (Intrabodies) and Their Therapeutic Potential
A. S. -Y. Lo, Q. Zhu, W. A. Marasco

DRM-restrictions

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Keywords: TECHNOLOGY & ENGINEERING / Biomedical TEC059000