Protein-Protein Interactions as New Drug Targets

I. Organization of Scaffolds

1. A-Kinase Anchoring Proteins as the Basis for cAMP Signaling
K. L. Dodge-Kafka, A. Bauman, M. S. Kapiloff

2. Arrestins as Multi-Functional Signaling Adaptors
V. V. Gurevich, E. V. Gurevich, W. M. Cleghorn

3. Role of Ena/VASP Proteins in Homeostasis and Disease
G. Pula, M. Krause

4. Scaffold/Matrix Attachment Regions (S/MARs): Relevance for Disease and Therapy
A. Gluch, M. Vidakovic, J. Bode

5. Clathrin/AP-2-Dependent Endocytosis: A Novel Playground for the Pharmacological Toolbox?
C. Rodemer, V. Haucke

II. Scaffolding Proteins and Cellular Signalling

6. PDE4 Associates with Different Scaffolding Proteins: Modulating Interactions as Treatment for Certain Diseases
A. C. McCahill, E. Huston, X. Li, M. D. Houslay

7. G-Protein-Coupled Receptor-Signaling Components in Membrane Raft and Caveolae Microdomains
H. H. Patel, F. Murray, P. A. Insel

8. Protein Scaffolds, Lipid Domains and Substrate Recognition in Protein Kinase C Function: Implications for Rational Drug Design
J. W. Walker

9. Compartmentalised MAPK Pathways
M. D. Brown, D. B. Sacks

10. Dynamic Protein Complexes Regulate NF-?B Signaling
E. Wegener, D. Krappmann

11. An Oncogenic Hub: ß-Catenin as a Molecular Target for Cancer Therapeutics
K. -I. Takemaru, M. Ohmitsu, F. -Q. Li

12. A Toolkit for Real-Time Detection of cAMP: Insights into Compartmentalized Signaling
M. Berrera, G. Dodoni, S. Monterisi, V. Pertegato, I. Zamparo, M. Zaccolo

III. Cell Type-Specific Anchoring

13. Scaffolding Proteins in Cardiac Myocytes
N. L. Chudasama, S. O. Marx, S. F. Steinberg

14. Molecular Architecture of Signal Complexes Regulating Immune Cell Function
K. M. Torgersen, E. M. Aandahl, K. Taskén

15. Scaffolding Proteins at the Postsynaptic Density: Shank as the Architectural Framework
H. -J. Kreienkamp

IV. Interference with Protein-Protein Interaction Sites as a New Pharmacological Concept

16. Domains Mediate Protein-Protein Interactions and Nucleate Protein Assemblies
S. Costa, G. Cesareni

17. Proline-Rich Sequence Recognition Domains (PRD): Ligands, Function and Inhibition
C. Freund, H. -G. Schmalz, J. Sticht, R. Kühne

18. Chemical Inhibition Through Conformational Stabilization of Rho GTPase Effectors
S. W. Deacon, J. R. Peterson

19. Pharmacological Interference with Protein-Protein Interactions Mediated by Coiled-Coil Motifs
H. M. Strauss, S. Keller

20. Direct AKAP-Mediated Protein-Protein Interactions as Potential Drug Targets
C. Hundsrucker, E. Klussmann

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Keywords: TECHNOLOGY & ENGINEERING / Biomedical TEC059000