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Bourne, H.

GPCRs: From Deorphanization to Lead Structure Identification

Bourne, H. - GPCRs: From Deorphanization to Lead Structure Identification, ebook

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ISBN: 9783540489825
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Table of contents

1. G-Proteins and GPCRs: From the Beginning
H. R. Bourne

2. Modeling GPCRs
A. C. M. Paiva†, L. Oliveira, F. Horn†, R. P. Bywater, G. Vriend

3. QSAR Modeling of GPCR Ligands: Methodologies and Examples of Applications
A. Tropsha, S. X. Wang

4. Privileged Structures in GPCRs
R. P. Bywater

5. Designing Compound Libraries Targeting GPCRs
E. Jacoby

6. Orphan Seven Transmembrane Receptor Screening
M. J. Wigglesworth, L. A. Wolfe, A. Wise

7. The Role of GPCR Dimerisation/Oligomerisation in Receptor Signalling
G. Milligan, M. Canals, J. D. Pediani, J. Ellis, J. F. Lopez-Gimenez

8. Deorphanization of G-Protein-Coupled Receptors
M. Parmentier, M. Detheux

9. Virus-Encoded G-Protein-Coupled Receptors: Constitutively Active (Dys)Regulators of Cell Function and Their Potential as Drug Target
H. F. Vischer, J. W. Hulshof, I. J. P. Esch, M. J. Smit, R. Leurs

10. Modulation of GPCR Conformationsby Ligands, G-Proteins, and Arrestins
E. R. Prossnitz, L. A. Sklar

11. High Content Screening to Monitor G Protein-Coupled Receptor Internalisation
R. Heilker

12. High-Throughput Lead Finding and Optimisation for GPCR Targets
A. Sewing, D. Cawkill

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Keywords: TECHNOLOGY & ENGINEERING / Biomedical TEC059000

Author(s)
 
 
 
Publisher
Springer
Publication year
2007
Language
en
Edition
1
Category
Medicine, Health Care, Mode
Format
Ebook
eISBN (PDF)
9783540489825

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