GPCRs: From Deorphanization to Lead Structure Identification

1. G-Proteins and GPCRs: From the Beginning
H. R. Bourne

2. Modeling GPCRs
A. C. M. Paiva†, L. Oliveira, F. Horn†, R. P. Bywater, G. Vriend

3. QSAR Modeling of GPCR Ligands: Methodologies and Examples of Applications
A. Tropsha, S. X. Wang

4. Privileged Structures in GPCRs
R. P. Bywater

5. Designing Compound Libraries Targeting GPCRs
E. Jacoby

6. Orphan Seven Transmembrane Receptor Screening
M. J. Wigglesworth, L. A. Wolfe, A. Wise

7. The Role of GPCR Dimerisation/Oligomerisation in Receptor Signalling
G. Milligan, M. Canals, J. D. Pediani, J. Ellis, J. F. Lopez-Gimenez

8. Deorphanization of G-Protein-Coupled Receptors
M. Parmentier, M. Detheux

9. Virus-Encoded G-Protein-Coupled Receptors: Constitutively Active (Dys)Regulators of Cell Function and Their Potential as Drug Target
H. F. Vischer, J. W. Hulshof, I. J. P. Esch, M. J. Smit, R. Leurs

10. Modulation of GPCR Conformationsby Ligands, G-Proteins, and Arrestins
E. R. Prossnitz, L. A. Sklar

11. High Content Screening to Monitor G Protein-Coupled Receptor Internalisation
R. Heilker

12. High-Throughput Lead Finding and Optimisation for GPCR Targets
A. Sewing, D. Cawkill

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Keywords: TECHNOLOGY & ENGINEERING / Biomedical TEC059000