Cohen, Patricia T.W.

Inhibitors of Protein Kinases and Protein Phosphates

Cohen, Patricia T.W. - Inhibitors of Protein Kinases and Protein Phosphates, ebook


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ISBN: 9783540266709
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Table of contents

1. Protein Kinase Inhibitors for the Treatment of Disease: The Promise and the Problems
P. Cohen

Part I. General Aspects of PKs Inhibition

2. New Design Strategies for Ligands That Target Protein Kinase-Mediated Protein-Protein Interactions
D. S. Lawrence

Part II. Pharmacological Potential and Inhibitors of Individual Classes of Protein Kinases

3. The Paullones: A Family of Pharmacological Inhibitors of Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3
L. Meijer, M. Leost, O. Lozach, S. Schmitt, C. Kunick

4. Pharmacological Potential of p38 MAPK Inhibitors
S. Kumar, S. M. Blake

5. Inhibitors of PKA and Related Protein Kinases
M. Gaßel, C. Breitenlechner, S. Herrero, R. Engh, D. Bossemeyer

6. Inhibitors of Protein Kinase CK2: Structural Aspects
R. Battistutta, S. Sarno, G. Zanotti

7. Aminoglycoside Kinases and Antibiotic Resistance
D. H. Fong, D. L. Burk, A. M. Berghuis

Part III. Pharmacological Potential and Inhibitors of Individual Classes of Protein Phosphatases

8. Protein Tyrosine Phosphatases as Therapeutic Targets
A. Cheng, N. Uetani, C. Lampron, M. L. Tremblay

9. Structure-Based Design of Protein Tyrosine Phosphatase Inhibitors
N. P. H. Møller, H. S. Andersen, C. B. Jeppesen, L. F. Iversen

10. Biological Validation of the CD45 Tyrosine Phosphatase as a Pharmaceutical Target
D. R. Alexander

11. Serine/Threonine Protein Phosphatase Inhibitors with Antitumor Activity
R. E. Honkanen

Part IV. Inhibitors in Clinical Use or Advanced Clinical Trials

12. Clinical Immunosuppression using the Calcineurin-Inhibitors Ciclosporin and Tacrolimus
N. R. Banner, H. Lyster, M. H. Yacoub

13. Targeted Therapy with Imatinib: An Exception or a Rule?
D. Fabbro, G. Fendrich, V. Guez, T. Meyer, P. Furet, J. Mestan, J. D. Griffin, P. W. Manley, S. W. Cowan-Jacob

14. Clinical Aspects of Imatinib Therapy
B. J. Druker

15. Isoquinolinesulfonamide: A Specific Inhibitor of Rho-Kinase and the Clinical Aspect of Anti-Rho-Kinase Therapy
H. Hidaka, Y. Suzuki, M. Shibuya, Y. Sasaki

16. Discovery and Development of Iressa: The First in a New Class of Drugs Targeted at the Epidermal Growth Factor Receptor Tyrosine Kinase
A. E. Wakeling


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Keywords: TECHNOLOGY & ENGINEERING / Biomedical TEC059000

Publication year
Medicine, Health Care, Mode

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