Müller, Sylke
Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery
Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling. Furthermore, state-of the art "omics" technologies are described and currently studied enzymatic drug targets are discussed. Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification. In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented.
Keywords: parasites, metabolic analysis, antiparasitic, drug discovery, design pathway, modelling
- Editor
- Müller, Sylke
- Cerdan, Rachel
- Radulescu, Ovidiu
- Selzer, Paul M.
- Publisher
- John Wiley and Sons, Inc.
- Publication year
- 2016
- Language
- en
- Edition
- 1
- Series
- Drug Discovery in Infectious Diseases
- Page amount
- 576 pages
- Category
- Medicine, Health Care, Mode
- Format
- Ebook
- eISBN (ePUB)
- 9783527694112
- Printed ISBN
- 9783527694099