Phosphodiesterases and Their Inhibitors

Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug.
Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE targets and their inhibitors. Drug development options for all major human PDE families are discussed and cover diverse therapeutic fields, such as neurological/psychiatric, cardiovascular/metabolic, pain, and allergy/respiratory diseases. Finally, emerging chemotherapeutic applications of PDE inhibitors against malaria and other tropical diseases are discussed.

Keywords: phosphodiesterases and their inhibitors, spiros liras, andrew s. bell, raimund mannhold, hugo kubinyi, gerd folkers, the pde gene family in drug discovery, pde-5 inhibitors for erectile dysfunction, pde-5 inhibitors, pde-10 inhibitors for schizophrenia, pde-9 inhibitors for cognitive deficits diseases, pde-4 inhibitors for cns indications