Lackey, Karen
Medicinal Chemistry Approaches to Personalized Medicine
Numerous case studies from the first generation of "personalized drugs" are presented, highlighting the challenges and opportunities for pharmaceutical development. While the majority of these examples are taken from the field of cancer treatment, other key emerging areas, such as neurosciences and inflammation, are also covered.
With its careful balance of current and future approaches, this handbook is a prime knowledge source for every drug developer, and one that will remain up to date for some time to come.
From the content:
* Discovery of Predictive Biomarkers for Anticancer Drugs
* Discovery and Development of Vemurafenib
* Targeting Basal-Cell Carcinoma
* G-Quadruplexes as Therapeutic Targets in Cancer
* From Human Genetics to Drug Candidates: An Industrial Perspective on LRRK2 Inhibition as a Treatment for Parkinson's Disease
* Therapeutic Potential of Kinases in Asthma
* DNA Damage Repair Pathways and Synthetic Lethality
* Medicinal Chemistry in the Context of the Human Genome
and many more
Keywords: Medicinal Chemistry Approaches to Personalized Medicine, Karen Lackey, Bruce D. Roth, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers, Crizotinib, Zelboraf, Vismodegib, DNA damage repair pathways and synthetic lethality, LRRK-2, Genes to drugs for CNS disorders, The Alzheimer's Prevention Initiation study, Kinases in asthma, Epigenetics, Developing targeted PET probes in the era of personalized medicine
- Editor
- Lackey, Karen
- Roth, Bruce
- Mannhold, Raimund
- Kubinyi, Hugo
- Folkers, Gerd
- Publisher
- John Wiley and Sons, Inc.
- Publication year
- 2014
- Language
- en
- Edition
- 1
- Series
- Methods & Principles in Medicinal Chemistry
- Page amount
- 350 pages
- Category
- Technology, Energy, Traffic
- Format
- Ebook
- eISBN (ePUB)
- 9783527677276