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Brown, Nathan

Scaffold Hopping in Medicinal Chemistry

Brown, Nathan - Scaffold Hopping in Medicinal Chemistry, ebook

156,25€

Ebook, ePUB with Adobe DRM
ISBN: 9783527665167
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This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader's own projects.
The first section serves as an introduction to the topic by describing the concept of scaffolds, their discovery, diversity and representation, and their importance for finding new chemical entities. The following parts contain a general description as well as case studies of the most common tools and methods for scaffold hopping, whether topological, shape-based or structure-based. The final part contains three fully documented real-world examples of successful drug development projects by scaffold hopping that illustrate the benefits of the approach for medicinal chemistry.
While most of the case studies are taken from medicinal chemistry, chemical and structural biologists will also benefit greatly from the insights presented here.

Keywords: Drug Discovery & Development, Scaffold Hopping in Medicinal Chemistry, Nathan Brown, Raimund Mannhold, Hugo Kubinyi, Gerd Folker, chemoinformatics tools, Markush structures and chemical patents, Feature trees (FTrees), XED Forcefields and Fieldstere, Molecular interaction fingerprints, mGluR5 inhibitors

Author(s)
 
 
 
Publisher
John Wiley and Sons, Inc.
Publication year
2014
Language
en
Edition
1
Series
Methods and Principles in Medicinal Chemistry
Page amount
350 pages
Category
Medicine, Health Care, Mode
Format
Ebook
eISBN (ePUB)
9783527665167
Printed ISBN
9783527333646

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