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Kalgutkar, Amit S.

Reactive Drug Metabolites

Kalgutkar, Amit S. - Reactive Drug Metabolites, ebook

117,40€

Ebook, ePUB with Adobe DRM
ISBN: 9783527655762
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Printing121 pages with an additional page accrued every 6 hours, capped at 121 pages
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Closing a gap in the scientific literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefit approach to managing the toxicity risk of reactive metabolite-prone drugs is presented.
Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.

Keywords: Drug Discovery & Development

Author(s)
 
 
 
 
 
 
Publisher
John Wiley and Sons, Inc.
Publication year
2012
Language
en
Edition
1
Series
Methods and Principles in Medicinal Chemistry
Page amount
402 pages
Category
Medicine, Health Care, Mode
Format
Ebook
eISBN (ePUB)
9783527655762
Printed ISBN
9783527330850

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