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Brown, Nathan

Bioisosteres in Medicinal Chemistry

Brown, Nathan - Bioisosteres in Medicinal Chemistry, ebook

133,90€

Ebook, ePUB with Adobe DRM
ISBN: 9783527654321
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Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.
The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed.
With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.

Keywords: Drug Discovery & Development

Author(s)
 
 
 
Publisher
John Wiley and Sons, Inc.
Publication year
2012
Language
en
Edition
1
Series
Methods and Principles in Medicinal Chemistry
Page amount
330 pages
Category
Medicine, Health Care, Mode
Format
Ebook
eISBN (ePUB)
9783527654321
Printed ISBN
9783527330157

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