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Dömling, Alexander

Protein-Protein Interactions in Drug Discovery

Dömling, Alexander - Protein-Protein Interactions in Drug Discovery, ebook

156,20€

Ebook, ePUB with Adobe DRM
ISBN: 9783527648221
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Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation.
The main part of the book describes examples of protein targets for which small molecule modulators have been developed, covering such diverse fields as cancer, autoimmune disorders and infectious diseases. Tailor-made for the practicing medicinal chemist, this ready reference includes a wide selection of case studies taken straight from the development pipeline of major pharmaceutical companies to illustrate the power and potential of this approach.

Keywords: Drug Discovery & Development, protein-protein interactions in drug discovery, protein-protein interactions, drug discovery, protein-protein, drug targets, medicinal chemist, cancer, autoimmune disorders, infectious diseases, pharmaceutical companies, small molecule modulators, protein targets, PPIs, small molecule ligands, molecule ligands, Alexander Dö, mling, biochemistry, biophysicists, biotechnologists, blockbuster drugs, development pipeline, intra-species, inter-species, systembs biology, Prediction of intra- and inter-species, Modulators of protein-protein interactions, Protein-Protein Interaction inhibitors, SH3 Domains as Drug Targets, P53 MDM2 Antagonists, Inhibition of LFA-1/ICAM interaction, PIF-binding pocket of AGC kinases, Retosiban, Epelsiban, Oxytocin Antagonists, Peptidic inhibitors, cell adhesion receptors, RGD peptides, REPLACE Strategy, Non-ATP competitive Inhibitors, Cell-Cycle Protein Kinases, protein science, biotechnology, drug development

Author(s)
 
 
 
Publisher
John Wiley and Sons, Inc.
Publication year
2013
Language
en
Edition
2
Series
Methods and Principles in Medicinal Chemistry
Page amount
480 pages
Category
Medicine, Health Care, Mode
Format
Ebook
eISBN (ePUB)
9783527648221
Printed ISBN
9783527331079

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