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Gohlke, Holger

Protein-Ligand Interactions

Gohlke, Holger - Protein-Ligand Interactions, ebook

183,80€

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ISBN: 9783527645961
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Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for development.
The first part provides a basic understanding of the factors governing protein-ligand interaction, followed by a comparison of the four key experimental methods (calorimetry, surface plasmon resonance, NMR and X-ray crystallography) used in generating interaction data. The second half of the book is devoted to in-silico methods of modeling and predicting molecular recognition and binding. Here, as elsewhere in the book, emphasis is placed on novel approaches and recent improvements to established methods. The final part looks at unresolved challenges, and the strategies to address them.
With the content relevant for all drug classes and therapeutic fields, this is an inspiring and often-consulted guide to the complexity of protein-ligand interaction modeling and analysis for both novices and experts.

Keywords: Drug Discovery & Development, calorimetry, surface plasmon resonance, NMR, x-ray crystallography, predicting molecular recognition, predicting molecular binding, protein-ligand interaction modeling, protein-ligand interaction analysis, ligand-target interactions

Author(s)
 
 
 
Publisher
John Wiley and Sons, Inc.
Publication year
2012
Language
en
Edition
1
Series
Methods and Principles in Medicinal Chemistry
Page amount
420 pages
Category
Medicine, Health Care, Mode
Format
Ebook
eISBN (ePUB)
9783527645961
Printed ISBN
9783527329663

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