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Waterbeemd, Han van de

Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability

Waterbeemd, Han van de - Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability, ebook

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ISBN: 9783527623877
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The gold standard for industrial research now completely revised in line with current trends in the field, with all contributions extensively updated or rewritten.

In 21 chapters readers can benefit from the key working knowledge of today's leading pharmaceutical companies, including Pfizer, AstraZeneca, and Roche. Drug developers from industry and academia present all the factors governing drug bioavailability, complete with practical examples and real-life data.

Part I focuses on in vitro and in vivo measurements of physicochemical properties, such as membrane permeability and ionization. Part II discusses solubility and gastrointestinal absorption, while the third part is devoted to metabolism and excretory mechanisms. The much revised and expanded part IV surveys current in silico approaches to predict drug properties needed to estimate the bioavailability of any new drug candidate. The final part shows how poor bioavailability may be improved by various approaches during the development process.

No other publication offers the same level of treatment on this crucial topic in modern drug development.

Author(s)
 
 
 
 
Publisher
John Wiley and Sons, Inc.
Publication year
2009
Language
en
Edition
1
Series
Methods and Principles in Medicinal Chemistry
Page amount
645 pages
Category
Medicine, Health Care, Mode
Format
Ebook
eISBN (PDF)
9783527623877
Printed ISBN
9783527320516

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