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Folkers, Gerd

Pharmacophores and Pharmacophore Searches

Folkers, Gerd - Pharmacophores and Pharmacophore Searches, ebook

145,20€

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ISBN: 9783527608720
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This handbook is the first to address the practical aspects of this novel method. It provides a complete overview of the field and progresses from general considerations to real life scenarios in drug discovery research.

Starting with an introductory historical overview, the authors move on to discuss ligand-based approaches, including 3D pharmacophores and 4D QSAR, as well as the concept and application of pseudoreceptors. The next section on structure-based approaches includes pharmcophores from ligand-protein complexes, FLIP and 3D protein-ligand binding interactions. The whole is rounded off with a complete section devoted to applications and examples, including modeling of ADME properties.

With its critical evaluation of pharmacophore-based strategies, this book represents a valuable aid for project leaders and decision-makers in the pharmaceutical industry, as well as pharmacologists, and medicinal and chemists.

Keywords: SCIENCE / Chemistry / Industrial & Technical SCI013060

Author(s)
 
 
 
 
Publisher
John Wiley and Sons, Inc.
Publication year
2007
Language
en
Edition
1
Series
Methods and Principles in Medicinal Chemistry
Page amount
395 pages
Category
Technology, Energy, Traffic
Format
Ebook
eISBN (PDF)
9783527608720
Printed ISBN
9783527312504

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