Folkers, Gerd
Pharmacophores and Pharmacophore Searches
Starting with an introductory historical overview, the authors move on to discuss ligand-based approaches, including 3D pharmacophores and 4D QSAR, as well as the concept and application of pseudoreceptors. The next section on structure-based approaches includes pharmcophores from ligand-protein complexes, FLIP and 3D protein-ligand binding interactions. The whole is rounded off with a complete section devoted to applications and examples, including modeling of ADME properties.
With its critical evaluation of pharmacophore-based strategies, this book represents a valuable aid for project leaders and decision-makers in the pharmaceutical industry, as well as pharmacologists, and medicinal and chemists.
Keywords: SCIENCE / Chemistry / Industrial & Technical SCI013060
- Author(s)
- Folkers, Gerd
- Hoffmann, Remy D.
- Kubinyi, Hugo
- Langer, Thierry
- Mannhold, Raimund
- Publisher
- John Wiley and Sons, Inc.
- Publication year
- 2007
- Language
- en
- Edition
- 1
- Series
- Methods and Principles in Medicinal Chemistry
- Page amount
- 395 pages
- Category
- Technology, Energy, Traffic
- Format
- Ebook
- eISBN (PDF)
- 9783527608720
- Printed ISBN
- 9783527312504