The centrosome controls the number and distribution of microtubules—a major element of the cell cytoskeleton—and hence influences many important cellular functions and properties. These include cell shape, polarity, and motility, as well as the intracellular transport and positioning of various organelles. Of particular interest, centrosome function is critical for chromosome segregation and cell division.
This book is meant to summarize our current knowledge of the structure, function and evolution of microtubule organizing centers, primarily centrosomes. Emphasis is on the role of these organelles in development and disease (particularly cancer).