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Childers, Wayne E.

Successful Drug Discovery

Childers, Wayne E. - Successful Drug Discovery, ebook

130,55€

Ebook, ePUB with Adobe DRM
ISBN: 9783527814718
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Printing82 pages with an additional page accrued every 9 hours, capped at 82 pages
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Provides unique insider insight into the current drug development process, and what it takes to achieve success

In this fourth volume in the series, inventors and primary developers of drugs that made it to the market continue telling the story of the drugs? discovery and development, and discuss the sometimes twisted route from the first drug candidate molecule to the final marketed one. Beginning with a general section addressing overarching topics for drug discovery, the book offers seven chapters that feature selected case studies describing recently introduced drugs or drug classes. These include small molecule drugs as well as biopharmaceuticals and range across different therapeutic fields. Together, they provide a representative cross-section of the present-day drug development effort.

Successful Drug Discovery: Volume 4 covers trends in peptide-based drug discovery and the physicochemical properties of recently approved oral drugs. The section on drug class studies looks at antibody-drug conjugates and the discovery, evolution, and therapeutic potential of dopamine partial agonists. Featured case studies examine the discovery of Etelcalcetide for the treatment of secondary hyper-parathyroidism in patients with chronic kidney disease; the development of Lenvatinib Mesylate; the discovery and development of Venetoclax; and more.

-Focuses on recently introduced drugs that have not been featured in any textbooks or general references, including Ocrelizumab, a new generation of anti-CD-20 mAb for the treatment of multiple sclerosis, and Venetoclax, a selective antagonist of BCL-2
-Features personal experiences of successful drug developers from industry and academia
-Endorsed and supported by the International Union of Pure and Applied Chemistry (IUPAC)

Successful Drug Discovery: Volume 4 provides a fascinating and informative look into the process of drug discovery and would be a great reference for those in the pharmaceutical industry, organic and pharmaceutical chemists, and lecturers in pharmacy.

Keywords: drugs; drug development effort; successful drug discovery; drug development process; drug candidate molecule; drug class studies; discovery; successful drug developers; drug discovery; peptide-based drug discovery; featured case studies, Organic Chemistry, Pharmacology & Pharmaceutical Medicine, Organic Chemistry, Pharmacology & Pharmaceutical Medicine

Editor
 
 
Publisher
John Wiley and Sons, Inc.
Publication year
2019
Language
en
Edition
1
Page amount
272 pages
Category
Medicine, Health Care, Mode
Format
Ebook
eISBN (ePUB)
9783527814718
Printed ISBN
9783527344680

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