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Erlanson, Daniel A.

Fragment-based Drug Discovery: Lessons and Outlook

Erlanson, Daniel A. - Fragment-based Drug Discovery: Lessons and Outlook, ebook

175,85€

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ISBN: 9783527683628
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From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed.

The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel and emerging methods for fragment screening, including empirical as well as computational approaches. Special cases of fragment-based screening, e. g. for complex target systems and for covalent inhibitors are also discussed. The third part presents several case studies from recent and on-going drug discovery projects for a variety of target classes, from kinases and phosphatases to targeting protein-protein interaction and epigenetic targets.

Keywords: fragment-based drug discovery, FBDD, drug target screening, kinase modeling, phosphatases, epigenetic medicinal chemistry, fragment screening, BACE inhibitors, kinase drug hunting, fragment-based drug discovery, FBDD, drug target screening, kinase modeling, phosphatases, epigenetic medicinal chemistry, fragment screening, BACE inhibitors, kinase drug hunting, Drug Discovery & Development

Editor
 
 
 
 
Publisher
John Wiley and Sons, Inc.
Publication year
2016
Language
en
Edition
1
Series
Methods and Principles in Medicinal Chemistry
Page amount
416 pages
Category
Medicine, Health Care, Mode
Format
Ebook
eISBN (ePUB)
9783527683628
Printed ISBN
9783527337750

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