The role of serendipity is analyzed in some very successful drugswhere the research targets of the lead molecule and the drug aredifferent. Phenotypic and target-based drug discovery approachesare discussed from the viewpoint of pioneer drugs and analogues.
This volume gives an excellent overview of insulin analoguesincluding a discussion of the properties of rapid-acting andlong-acting formulations of this important hormone.
The major part of the book is devoted to case histories of new drugdiscoveries described by their key inventors. Eight case historiesrange across many therapeutic fields.
The goal of this book series is to help the participants of thedrug research community with a reference book series and to supportteaching in medicinal chemistry with case histories and reviewarticles of new drugs.
Keywords: Drug Discovery & Development, small molecule drug biological biopharmaceutics serendipity Avanafil Dapagliflozin Elvitegravir Linagliptin Pemetrexed Perampanel Telaprevir Trastuzumab Emtansine