Otzen, Daniel Erik

Amyloid Fibrils and Prefibrillar Aggregates: Molecular and Biological Properties

Otzen, Daniel Erik - Amyloid Fibrils and Prefibrillar Aggregates: Molecular and Biological Properties, ebook


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ISBN: 9783527654208
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Summing up almost a decade of biomedical research, this topical and eagerly awaited handbook is the first reference on the topic to incorporate recent breakthroughs in amyloid research.

The first part covers the structural biology of amyloid fibrils and pre-fibrillar assemblies, including a description of current models for amyloid formation. The second part looks at the diagnosis and biomedical study of amyloid in humans and in animal models, while the final section discusses pharmacological approaches to manipulating amyloid and also looks at its physiological roles in lower and higher organisms. For Biochemists, Molecular Biologists, Neurobiologists, Neurophysiologists and those working in the Pharmaceutical Industry.

Keywords: Amyloid Fibrils and Prefibrillar Aggregates, Amyloid Fibrils, Prefibrillar Aggregates, amyloid proteins, amyloid research, pre-fibrillar, pharmacological approaches, manipulating amyloid, amyloid in humans, biomedical research, daniel erik otzen, protein science, protein bioscience, molecular biology, neurophysiology, neurobiology, alzheimer's disease, parkinson's disease, neurodegenerative, Amyloid structure at the atomic level, crystallography, solid state NMR, Amyloid architecture, electron microscropy, fiber diffraction, Structures of aggregating species, SAXS, Pathways of amyloid formation, Amyloid bioinformatics, Mechanisms of amyloid formation, theory, comparative evaluation of different models, secondary nucleation, Detecting amyloid, conformational antibodies, luminescent polymers, Amyloid animal models, Amyloidoses - from the molecular perspective, oligomer species, cytotoxicity, structures and stabilities, experimental approaches to inducing amyloid, Amyloid polymorphism, Inhibitors of amyloid and oligomer formation, Drug approaches against amyloidosis, Amyloid as nanomaterials, Functional amyloid in bacteria, Amyloid as storage states, Structural Biology, Molecular Biology (Medical), Structural Biology, Molecular Biology (Medical)

John Wiley and Sons, Inc.
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464 pages
Natural Sciences
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