Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity

Part I. Immune Checkpoint Cells

1. Regulatory T Cells: Molecular and Cellular Basis for Immunoregulation
Yosuke Togashi, Hiroyoshi Nishikawa

2. Overview of LAG-3-Expressing, IL-10-Producing Regulatory T Cells
Keishi Fujio, Kazuhiko Yamamoto, Tomohisa Okamura

3. Regulatory Dendritic Cells
Katsuaki Sato, Tomofumi Uto, Tomohiro Fukaya, Hideaki Takagi

Part II. Extracellular Immune Checkpoint Molecules

4. Role of PD-1 in Immunity and Diseases
Kenji Chamoto, Muna Al-Habsi, Tasuku Honjo

5. CTLA-4, an Essential Immune-Checkpoint for T-Cell Activation
Shunsuke Chikuma

6. Tim-3, Lag-3, and TIGIT
Nicole Joller, Vijay K. Kuchroo

Part III. Intracelluar Immune Checkpoint Molecules

7. SOCS1: Regulator of T Cells in Autoimmunity and Cancer
Subburaj Ilangumaran, Diwakar Bobbala, Sheela Ramanathan

8. Mining the Complex Family of Protein Tyrosine Phosphatases for Checkpoint Regulators in Immunity
Claudia Penafuerte, Luis Alberto Perez-Quintero, Valerie Vinette, Teri Hatzihristidis, Michel L. Tremblay

9. Immune Regulation by Ubiquitin Tagging as Checkpoint Code
Peng Zeng, Jieyu Ma, Runqing Yang, Yun-Cai Liu

10. MicroRNA in Immune Regulation
Cheng-Jang Wu, Li-Fan Lu

Keywords: Biomedicine, Immunology, Cancer Research, Cell Biology