Garcia-Reyero, Natàlia

A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment

Garcia-Reyero, Natàlia - A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment, ebook


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Table of contents

1. Advancing Adverse Outcome Pathways for Risk Assessment
Natàlia Garcia-Reyero, Cheryl A. Murphy

2. Use of High-Throughput and Computational Approaches for Endocrine Pathway Screening
Patience Browne, Warren M. Casey, David J. Dix

3. Cell-Free Assays in Environmental Toxicology
Adeline Arini, Krittika Mittal, Niladri Basu

4. The Fish Embryo as a Model for AOP Development
Lucia Vergauwen, Steven Cruchten, Dries Knapen

5. Invertebrate Model Species in AOP Development
Geoff Hodges, Steve Gutsell, Nadine Taylor, Erica Brockmeier, Emma Butler, Cecilie Rendal, John Colbourne

6. Non-model Species in Ecological Risk Assessment
Markus Hecker

7. Green Algae and Networks for Adverse Outcome Pathways
Anze Zupanic, Smitha Pillai, Diana Coman Schmid, Kristin Schirmer

8. Neurobehavioral Analysis Methods for Adverse Outcome Pathway (AOP) Models and Risk Assessment
Francisco X. Mora-Zamorano, Jeremy K. Larson, Michael J. Carvan

9. The Application of Omics Data to the Development of AOPs
Mary T. McBride

10. Use of Genetic Manipulation for Evaluating and Understanding Adverse Outcome Pathways
Christopher Warner, Natàlia Garcia-Reyero, Edward Perkins

11. Considering Epigenetics in Adverse Outcome Pathways
Kristine L. Willett

12. Tiered Approaches to Incorporate the Adverse Outcome Pathway Framework into Chemical-Specific Risk-Based Decision Making
Jeremy Leonard, Shannon Bell, Noffisat Oki, Mark Nelms, Yu-Mei Tan, Stephen Edwards

13. The Development of Quantitative AOPs
Irvin R. Schultz, Karen H. Watanabe

14. Linking Adverse Outcome Pathways to Dynamic Energy Budgets: A Conceptual Model
Cheryl A. Murphy, Roger M. Nisbet, Philipp Antczak, Natàlia Garcia-Reyero, Andre Gergs, Konstadia Lika, Teresa Mathews, Erik B. Muller, Diane Nacci, Angela Peace, Christopher H. Remien, Irvin R. Schultz, Karen H. Watanabe

15. Weight of Evidence Frameworks in Evaluation of Adverse Outcome Pathways
Taylor Rycroft, Olivia Massey, Christy M. Foran, Igor Linkov

16. Using a Vitellogenesis Model to Link in vitro Neurochemical Effects of Pulp and Paper Mill Effluents to Adverse Reproductive Outcomes in Fish
Brandon M. Armstrong, Cheryl A. Murphy, Niladri Basu

17. Use of Adverse Outcome Pathways in Human Risk Assessment and Toxicology
Catherine Willett, Suzanne Fitzpatrick, Bette Meek, Carl Westmoreland

18. Use and Acceptance of AOPs for Regulatory Applications
Clemens Wittwehr

19. The Future of Adverse Outcome Pathways: Analyzing their Social Context
Kevin C. Elliott, Cheryl A. Murphy, Natàlia Garcia-Reyero

Keywords: Life Sciences, Systems Biology, Pharmacology/Toxicology

Publication year
Page amount
14 pages
Natural Sciences
Printed ISBN

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